Gestational trophoblastic diseases: 3. Human chorionic gonadotropin-free beta-subunit, a reliable marker of placental site trophoblastic tumors

Gynecologic Oncology
L A ColeRoss S Berkowitz

Abstract

Placental site trophoblastic tumor (PSTT) commonly presents with low and variable concentration of hCG immunoreactivity in serum which can be difficult to differentiate from early stage choriocarcinoma/gestational trophoblastic neoplasm (GTN) or quiescent gestational trophoblastic disease (quiescent GTD). Nontrophoblastic malignancies such as germ cell tumors or other tumors secreting low hCG must also be considered in the differential diagnosis. Because treatments for these conditions are different, a means of differentiating PSTT from other diagnoses is important. We investigate the usefulness of hCG-free beta-subunit to make this discrimination. Data collected on cases referred to the USA hCG Reference Service for consultation served as a basis for this retrospective analysis. There were 13 cases with histology proven PSTT and 12 with nontrophoblastic malignancy. hCG-free beta-subunit was measured by immunoassay and reported as a proportion of total hCG (hCG-free beta-subunit(%)). hCG-free beta-subunit(%) results were determined for all histologically proven cases of PSTT and for the nontrophoblastic malignancies. Comparisons of hCG-free beta-subunit(%) were made and compared with those of the 82 choriocarcinoma/GTN cases an...Continue Reading

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Jan 28, 2009·Reproductive Biology and Endocrinology : RB&E·Laurence A Cole
Aug 17, 2011·Reviews in Endocrine & Metabolic Disorders·Prajna Banerjee, Asgerally T Fazleabas
Aug 19, 2007·Journal of Cancer Research and Clinical Oncology·Nadereh Behtash, Mojgan Karimi Zarchi
Sep 4, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M J SecklUNKNOWN ESMO Guidelines Working Group
Mar 16, 2007·The New England Journal of Medicine·Laurence A ColeCarolyn Y Muller
Jul 1, 2009·Expert Opinion on Medical Diagnostics·Tsui-Lien Mao, Ie-Ming Shih
Nov 15, 2008·Gynecologic Oncology·Carolyn Y Muller, Laurence A Cole
Sep 30, 2016·Iranian Journal of Radiology : a Quarterly Journal Published by the Iranian Radiological Society·Maryam NiknejadiFarnaz Akhbari
Feb 20, 2007·American Journal of Obstetrics and Gynecology·Ernest Kohorn
Mar 4, 2008·American Journal of Obstetrics and Gynecology·Laurence A ColeCarolyn Y Muller
Apr 28, 2009·American Journal of Obstetrics and Gynecology·Gihad Elias ChalouhiDaniel Raudrant
May 25, 2010·Clinical Biochemistry·Laurence A ColeCarolyn Y Muller
Oct 15, 2008·Gynecologic Oncology·Ross S Berkowitz, Donald P Goldstein
Dec 8, 2009·Gynecologic Oncology·Diljeet K Singh, John R Lurain
Sep 18, 2007·Obstetrical & Gynecological Survey·Tandy G OlsenJeremy A King
Mar 13, 2010·Journal of Korean Neurosurgical Society·Ji Hoon LeeWoo Kyung Kim
Oct 21, 2010·Expert Opinion on Pharmacotherapy·Noah RodriguezRoss S Berkowitz
Apr 1, 2008·Clinical Chemistry·Zhimin Tim Cao, Robert Rej
Feb 13, 2015·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Baljeet KaurNeil J Sebire
Dec 10, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Laurence A ColeCarolyn Y Muller
Oct 23, 2018·Journal of Immunoassay & Immunochemistry·Dayamin Martinez BritoRodny Montes De Oca Porto
Jan 9, 2010·Fetal and Pediatric Pathology·N J Sebire, Iain Lindsay
Jan 9, 2021·Obstetrics and Gynecology·John T Soper
Jan 2, 2021·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Lua EirikssonPhilippe Sauthier
Nov 4, 2020·Best Practice & Research. Clinical Obstetrics & Gynaecology·Barry W Hancock, John Tidy
Dec 27, 2011·Gynecologic Oncology·Laurence A Cole

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