Getting a chemical handle on protein post-translational modification

Organic & Biomolecular Chemistry
William P Heal, Edward W Tate

Abstract

This article highlights the emerging field of chemical proteomics, a powerful technology for the study of post- and co-translational modification of proteins. Genome mapping and the study of protein post-translational modifications have revealed the astounding chemical complexity present in the proteome of even the simplest organisms. The identification and characterisation of the modifications present on specific proteins in such complex mixtures has become a central challenge for post-genomic functional studies in cell and systems biology. In the chemical proteomic approach to this problem, protein-modifying enzymes and bioorthogonal chemoselective elaboration are exploited to deliver chemical tags to specific modified residues, enabling new advances in our understanding of protein modification.

References

Mar 21, 1989·Biochemistry·K Srinivasachar, D M Neville
Jan 1, 1996·Annual Review of Biochemistry·F L Zhang, P J Casey
Jun 18, 1997·Biochemical and Biophysical Research Communications·R L Edelstein, M D Distefano
Mar 7, 2000·Lancet·A KhwajaB M Hendry
Mar 17, 2000·Science·E Saxon, C R Bertozzi
Oct 14, 2000·Annual Review of Cell and Developmental Biology·F Melchior
Mar 28, 2001·Science·C R Bertozzi, L L Kiessling
Apr 3, 2001·Nature Biotechnology·H ZhouR Aebersold
Apr 21, 2001·Oncogene·C A Chen, D R Manning
Jun 9, 2001·The Journal of Organic Chemistry·O MelnykH Gras-Masse
Jul 27, 2001·Current Opinion in Chemical Biology·P J AlaimoK M Shokat
Nov 1, 2001·Annual Review of Cell and Developmental Biology·E Saxon, C R Bertozzi
Feb 14, 2002·Trends in Molecular Medicine·Miguel C SeabraAlistair N Hume
Aug 2, 2002·Expert Opinion on Investigational Drugs·Nafsika H Georgopapadakou
Feb 5, 2003·Current Opinion in Biotechnology·Douglas A Jeffery, Matthew Bogyo
Mar 4, 2003·EMBO Reports·Alexis VergerMerlin Crossley
Mar 7, 2003·Molecular Cell·Olena PylypenkoKirill Alexandrov
May 8, 2003·Molecular & Cellular Proteomics : MCP·Sung Won KwonYingming Zhao
Jul 23, 2003·Nature Biotechnology·Junmin PengSteven P Gygi
Jul 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·David J VocadloCarolyn R Bertozzi
Nov 11, 2003·Trends in Biochemical Sciences·Frauke MelchiorAndrea Pichler
Dec 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Howard C HangCarolyn R Bertozzi
Dec 18, 2003·Drug Discovery Today·Hartmuth C Kolb, K Barry Sharpless
Dec 25, 2003·Journal of the American Chemical Society·Nelly KhidekelLinda C Hsieh-Wilson
Dec 26, 2003·Chembiochem : a European Journal of Chemical Biology·Anna E Speers, Benjamin F Cravatt
Mar 16, 2004·The Journal of Biological Chemistry·Yingming ZhaoMichael A White
May 5, 2004·Chemistry & Biology·Anna E Speers, Benjamin F Cravatt
May 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Sanjai KumarZhong-Yin Zhang
Jun 17, 2004·Angewandte Chemie·Maja Köhn, Rolf Breinbauer
Jul 9, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Amy M Cline, Marko Z Radic
Aug 7, 2004·Current Biology : CB·Francisco J Herrera, Steven J Triezenberg
Aug 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yoonjung KhoYingming Zhao
Aug 20, 2004·Nature·Jennifer A PrescherCarolyn R Bertozzi
Sep 2, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nelly KhidekelLinda C Hsieh-Wilson
Sep 24, 2004·Biochemistry·Sarah J LuchanskyCarolyn R Bertozzi
Nov 13, 2004·Proteomics·Joerg ReindersAlbert Sickmann
Dec 17, 2004·Organic & Biomolecular Chemistry·Paul F van SwietenHerman S Overkleeft
Jan 18, 2005·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Alicia B BergerMatthew Bogyo
Jun 15, 2005·Journal of Proteome Research·Robert SprungYingming Zhao
Jun 22, 2005·Expert Review of Proteomics·Daniel S Sem
Jun 22, 2005·Expert Review of Proteomics·Thomas Kislinger, Andrew Emili
Jun 25, 2005·The Journal of Biological Chemistry·Muh-Ching YeeKarlene A Cimprich
Jul 14, 2005·Journal of the American Chemical Society·Anna E Speers, Benjamin F Cravatt

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Citations

Jun 20, 2013·Journal of Proteomics·Martin ČernýBřetislav Brzobohatý
Jun 24, 2011·Chemical Reviews·Jonathan Z Long, Benjamin F Cravatt
Oct 3, 2012·Molecular & Cellular Proteomics : MCP·Yinliang YangSteven H L Verhelst
Apr 25, 2013·Parasitology·Edward W TateMegan H Wright
May 29, 2014·Journal of Fluorescence·Cheng-Yin HuangAn-Tai Wu
Jun 23, 2011·Organic & Biomolecular Chemistry·Marco FiliceJose M Palomo
Dec 9, 2014·ACS Chemical Biology·Christian Hedberg, Aymelt Itzen
Jul 14, 2010·Chembiochem : a European Journal of Chemical Biology·Lianne I WillemsHerman S Overkleeft
Apr 7, 2011·Chemistry : a European Journal·Momoko KitaokaNoriho Kamiya
Mar 23, 2012·Angewandte Chemie·Lianne I WillemsHerman S Overkleeft
Jan 4, 2012·Chembiochem : a European Journal of Chemical Biology·Malgorzata BroncelEdward W Tate
Nov 1, 2013·Chembiochem : a European Journal of Chemical Biology·Matthias P MüllerChristian Hedberg
Nov 19, 2014·Angewandte Chemie·Oliver ReimannChristian P R Hackenberger
Jan 30, 2013·Biochemical Society Transactions·Elisabeth M StorckEdward W Tate
Jul 15, 2011·Bioorganic & Medicinal Chemistry·T H Tam DangEdward W Tate
May 12, 2015·ACS Combinatorial Science·Essam Hamied Ahmed Hanashalshahaby, Canan Unaleroglu
Sep 2, 2011·Bioorganic & Medicinal Chemistry·Geoffray LericheAlain Wagner
Apr 26, 2011·Chemistry & Biology·Remigiusz Serwa, Edward W Tate
Oct 5, 2010·Chemical Society Reviews·William P HealEdward W Tate
Nov 15, 2011·Organic & Biomolecular Chemistry·Karen Ka-Yan KungMan-Kin Wong
Apr 8, 2015·Biochemical Society Transactions·Paulina CieplaEdward W Tate
May 8, 2013·Chemical Communications : Chem Comm·Yinliang Yang, Steven H L Verhelst
Jan 29, 2021·Molecular Omics·Hester A BeardSteven H L Verhelst
Dec 15, 2016·Chemical Reviews·Krishnan K Palaniappan, Carolyn R Bertozzi

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