PMID: 8937827Oct 1, 1996Paper

Getting hydrophilic compounds into cells: lessons from homeopeptides

Current Opinion in Neurobiology
A Prochiantz

Abstract

The homeodomain of Antennapedia, a Drosophila transcription factor, translocates across biological membranes. Within this 60-amino-acid polypeptide, a shorter sequence of 16 amino acids was identified that can be used as an internalization vector for several types of cargo (i.e. other peptides and oligonucleotides) into the cytoplasm and nucleus of all cell types. This article describes our present understanding of this phenomenon and discusses its potential applications in cell biology.

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Citations

Dec 3, 1999·Journal of Neuroscience Research·J LilienJ Balsamo
May 14, 1999·Journal of Peptide Science : an Official Publication of the European Peptide Society·A SchellerM Bienert
Sep 24, 2004·Journal of Molecular Recognition : JMR·Johannes OehlkeMichael Bienert
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Sep 6, 2000·The European Journal of Neuroscience·S J BoltonF S Walsh
Dec 17, 2004·Nucleic Acids Research·Faye A RogersPeter M Glazer
Mar 11, 2004·European Journal of Biochemistry·Bart ChristiaensMaryvonne Rosseneu
Feb 10, 2000·Annals of the New York Academy of Sciences·A Prochiantz
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