Getting "Inside" Type I IFNs: Type I IFNs in Intracellular Bacterial Infections

Journal of Immunology Research
Deann T SnyderMark A Jutila

Abstract

Type I interferons represent a unique and complex group of cytokines, serving many purposes during innate and adaptive immunity. Discovered in the context of viral infections, type I IFNs are now known to have myriad effects in infectious and autoimmune disease settings. Type I IFN signaling during bacterial infections is dependent on many factors including whether the infecting bacterium is intracellular or extracellular, as different signaling pathways are activated. As such, the repercussions of type I IFN induction can positively or negatively impact the disease outcome. This review focuses on type I IFN induction and downstream consequences during infection with the following intracellular bacteria:Chlamydia trachomatis,Listeria monocytogenes,Mycobacterium tuberculosis,Salmonella entericaserovar Typhimurium,Francisella tularensis,Brucella abortus,Legionella pneumophila, andCoxiella burnetii. Intracellular bacterial infections are unique because the bacteria must avoid, circumvent, and even co-opt microbial "sensing" mechanisms in order to reside and replicate within a host cell. Furthermore, life inside a host cell makes intracellular bacteria more difficult to target with antibiotics. Because type I IFNs are important imm...Continue Reading

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Dec 7, 2017·Frontiers in Microbiology·Christiane ForestierPascale Gueirard
Mar 20, 2019·Frontiers in Cellular and Infection Microbiology·Wolfgang EisenreichWerner Goebel
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Jun 19, 2021·Frontiers in Medicine·Iris StolzerClaudia Günther

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