Getting to the guts of HIV pathogenesis

The Journal of Experimental Medicine
Ronald S Veazey, Andrew A Lackner

Abstract

Two groups have shown that, as in macaques infected with simian immunodeficiency virus (SIV), intestinal CD4(+) T cells are selectively and rapidly depleted in the intestine of HIV-infected patients. Depletion of intestinal CD4(+) T cells occurred at all stages of infection regardless of highly active antiretroviral therapy (HAART). Here we discuss the important implications of these papers for our understanding of HIV pathogenesis, treatment, and vaccine design.

References

Nov 8, 2001·Trends in Immunology·R S VeazeyA A Lackner
Feb 25, 2003·The Journal of Infectious Diseases·Ronald S VeazeyAndrew A Lackner
Jul 30, 2003·Journal of Virology·Ronald S VeazeyAndrew A Lackner
Sep 15, 2004·The Journal of Experimental Medicine·Jason M BrenchleyDaniel C Douek

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Citations

Feb 10, 2007·Nature Medicine·Erika Check
Feb 24, 2006·Nature Reviews. Immunology·Marian R Neutra, Pamela A Kozlowski
Jun 19, 2012·AIDS·Thumbi Ndung'u, Robin A Weiss
May 22, 2009·Journal of Virology·Matthew D H LayMiles P Davenport
May 28, 2013·Retrovirology·Natasja G de Groot, Ronald E Bontrop
Apr 26, 2006·Expert Opinion on Investigational Drugs·Priscilla BiswasGiuseppe Tambussi
Sep 18, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Rute NunesJosé das Neves
Apr 30, 2009·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Kenneth C Williams, Tricia H Burdo
Jun 19, 2013·Immunological Reviews·Huanbin XuRonald S Veazey
May 9, 2006·Trends in Immunology·Zdenek HelJiri Mestecky
Dec 10, 2014·Clinical Lymphoma, Myeloma & Leukemia·Adan Rios
Aug 26, 2016·Clinical Microbiology Reviews·Véronique Avettand-FènoëlChristine Rouzioux

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Methods Mentioned

BETA
biopsies

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