GeVaDSs - decision support system for novel Genetic Vaccine development process.

BMC Bioinformatics
Jacek BlazewiczPawel Wojciechowski

Abstract

The lack of a uniform way for qualitative and quantitative evaluation of vaccine candidates under development led us to set up a standardized scheme for vaccine efficacy and safety evaluation. We developed and implemented molecular and immunology methods, and designed support tools for immunization data storage and analyses. Such collection can create a unique opportunity for immunologists to analyse data delivered from their laboratories. We designed and implemented GeVaDSs (Genetic Vaccine Decision Support system) an interactive system for efficient storage, integration, retrieval and representation of data. Moreover, GeVaDSs allows for relevant association and interpretation of data, and thus for knowledge-based generation of testable hypotheses of vaccine responses. GeVaDSs has been tested by several laboratories in Europe, and proved its usefulness in vaccine analysis. Case study of its application is presented in the additional files. The system is available at: http://gevads.cs.put.poznan.pl/preview/(login: viewer, password: password).

References

Nov 21, 2007·Nucleic Acids Research·Zuoshuang XiangYongqun He
Nov 26, 2008·Nature Immunology·Troy D QuerecBali Pulendran
Oct 2, 2009·Clinical and Vaccine Immunology : CVI·Stanley A Plotkin
Nov 11, 2009·Science·Andrew W ParkBryan T Grenfell
May 17, 2011·Current Opinion in Immunology·Ann L ObergGregory A Poland

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Citations

Jan 24, 2014·Computational and Mathematical Methods in Medicine·Szymon WasikJacek Blazewicz
Dec 7, 2013·Artificial Intelligence in Medicine·Szymon WasikJacek Blazewicz
Sep 19, 2016·BMC Bioinformatics·Maciej AntczakJacek Blazewicz

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Software Mentioned

Linux
Excel
VIOLIN
GeVaDSs
Flash Player
Apache
GeVaDSs ( Genetic Vaccine Decision Support system )
R
PostgreSQL
Flex

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