GFRalpha-4, a new GDNF family receptor

Molecular and Cellular Neurosciences
J ThompsonA M Davies

Abstract

GFRalpha-1, GFRalpha-2, and GFRalpha-3 constitute a family of structurally related, glycosyl-phosphatidylinosital-linked, cell surface proteins, two of which, GFRalpha-1 and GFRalpha-2, are components of the receptor complex for the neurotrophic factors GDNF and neurturin, respectively. By screening an embryonic chicken brain cDNA library with a GFRalpha-1 probe at low stringency, we isolated cDNAs encoding an additional member of the GFRalpha family, GFRalpha-4. The nucleotide sequence predicts a 431-amino-acid secreted protein that is more closely related to GFRalpha-1 and GFRalpha-2 than to GFRalpha-3. GFRalpha-4 mRNA is expressed in distinctive patterns in the brain and several other organs and tissues of the chicken embryo. Our findings extend the family of GFRalpha proteins and provide information about the tissues in which GFRalpha-4 may function during development.

References

Jul 5, 1991·Science·S DavisG D Yancopoulos
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·H T MountI B Black
Oct 10, 1995·Proceedings of the National Academy of Sciences of the United States of America·L LiL J Houenou
Dec 20, 1994·Neuroreport·C Suter-Crazzolara, K Unsicker
Jun 1, 1994·Experimental Neurology·J E SpringerJ Q Trojanowski
Dec 1, 1993·Experimental Neurology·D G SchaarI B Black
Jun 27, 1996·Nature·P DurbecM Saarma
Jul 4, 1996·Nature·M W MooreA Rosenthal
Jul 4, 1996·Nature·J J TreanorA Rosenthal
Apr 1, 1996·Molecular and Cellular Neurosciences·I D BakaV L Buchman
Nov 1, 1996·Cell and Tissue Research·L J HouenouD Prevette
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·Q C VegaG R Dressler
Feb 7, 1997·Science·D L Choi-LundbergM C Bohn
Mar 1, 1997·The European Journal of Neuroscience·N A PochonP Aebischer
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·M SanicolaR L Cate
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·D J CreedonE M Johnson
Jan 31, 1998·The Journal of Biological Chemistry·S JingG M Fox
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·P NaveilhanP Ernfors

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Citations

Oct 13, 2006·Pituitary·Yoshiki MurakumoMasahide Takahashi
Sep 7, 2001·Cytokine & Growth Factor Reviews·M Takahashi
Apr 2, 1999·The European Journal of Neuroscience·Z KokaiaM Saarma
Nov 21, 2002·Neurochemistry International·Kimiko TokugawaShigeru Okuyama
Dec 13, 2006·Molecular and Cellular Neurosciences·Tuomas HätinenMatti S Airaksinen
Sep 28, 2005·Trends in Biochemical Sciences·Kellye C KirkbrideGerard C Blobe
Jun 22, 2000·Molecular and Cellular Neurosciences·M LindahlM S Airaksinen
Jun 5, 1999·Molecular and Cellular Neurosciences·M S AiraksinenM Saarma
Jul 17, 1999·Critical Reviews in Clinical Laboratory Sciences·R P Kapur
Dec 18, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M SukumaranV Pachnis
Jan 28, 2003·Journal of Neuroscience Research·Gita PezeshkiJürgen Engele
Jun 20, 2000·Diseases of the Colon and Rectum·C H KnowlesB A Ponder
Aug 17, 2006·Brain, Behavior and Evolution·Matti S AiraksinenTuomas Hätinen
Jun 26, 1999·Microscopy Research and Technique·M Saarma, H Sariola
Aug 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C Eng
Jun 29, 1999·Molecular and Cellular Neurosciences·A ForgieA M Davies
Mar 10, 2001·Developmental Biology·I T ShepherdD W Raible

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