PMID: 3751554Jul 1, 1986Paper

GH deficient children receiving GH replacement do not grow during intermittent infectious illness

Acta paediatrica Scandinavica
M HermanussenW G Sippell

Abstract

Five growth hormone deficient children, aged 5.3 to 12.6 yrs, were measured regularly once or twice weekly by knemometry, a novel and noninvasive technique of accurate lower leg length measurement. The total period of observation was 40 months in the 5 children. During this time all children received replacement therapy with extractive human pituitary growth hormone 12 IU/m2/week by daily s.c. injections. 11 intermittent infectious illnesses occurred within the observation period of 40 months. During the infectious diseases a significant decrease of the mean lower leg growth velocity down to -0.012 mm/day was observed. During the following convalescent period (14 days) mean lower leg growth velocity rose up to +0.107 mm/day (p less than 0.001). Growth hormone substitution was not changed throughout the period of observation.

Citations

May 1, 1988·European Journal of Pediatrics·M Hermanussen
Nov 1, 1996·Archives of Disease in Childhood·N K ThalangeP E Clayton
Jul 21, 1990·BMJ : British Medical Journal·O D Wolthers, S Pedersen
Mar 1, 1988·Annals of Human Biology·M HermanussenW G Sippell
Feb 9, 2016·American Journal of Physical Anthropology·Samuel S UrlacherLawrence S Sugiyama
Mar 1, 1993·Acta Paediatrica·L GrecoG de Ritis
Jan 1, 1993·American Journal of Human Biology : the Official Journal of the Human Biology Council·Michelle Lampl
Jan 1, 1993·American Journal of Human Biology : the Official Journal of the Human Biology Council·Virginia A Stallings, Christine E Cronk

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