GH elevates serum IGF-I levels but does not alter mucosal atrophy in parenterally fed rats

The American Journal of Physiology
C A PetersonD M Ney

Abstract

Growth hormone (GH) action is primarily mediated by insulin-like growth factor I (IGF-I), although both growth factors show tissue-selective effects. We investigated the effects of GH, IGF-I, and GH plus IGF-I on jejunal growth and function in rats maintained with total parenteral nutrition (TPN) and given recombinant human GH (rhGH) (400 micrograms/day sc, twice daily) and/or rhIGF-I (800 micrograms/day in TPN solution) for 5 days. Administration of GH or IGF-I alone produced similar increases in serum IGF-I levels and body weight; GH plus IGF-I further increased these parameters. TPN reduced mucosal mass, protein and DNA content, villus height, crypt depth, and enterocyte migration rate. IGF-I or GH plus IGF-I produced equivalent increases in all intestinal growth parameters; GH alone had no effect. GH, IGF-I, or GH plus IGF-I reduced TPN-induced increases in sucrase-specific activity. IGF-I, but not GH, attenuated TPN-induced increases in tissue conductance and carbachol-stimulated ion secretion. In contrast to IGF-I, GH does not stimulate intestinal growth during TPN and has less effect on normalizing TPN-induced changes in epithelial function.

Citations

Sep 12, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kristen L WilliamsP Kay Lund
Sep 8, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·J G SimmonsP K Lund
Feb 24, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·A N Alexander, H V Carey
May 24, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Elizabeth M DahlyDenise M Ney
Nov 30, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·S M SecorJ Diamond
Apr 1, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Carmen Z MichayliraP Kay Lund
Feb 3, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Gaëlle BoudryMary H Perdue
Jun 12, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Megan D BaumlerGuy E Groblewski
Dec 31, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Elizabeth M DahlyDenise M Ney
May 9, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·M B GillinghamD M Ney
Jul 18, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Heather R WilkinsP Kay Lund
Apr 16, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Shira FruchtmanP Kay Lund
Oct 17, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·J E ConourH R Gaskins
Aug 14, 2002·World Journal of Gastroenterology : WJG·Yan Gu, Zhao-Han Wu

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