GH increases extracellular volume by stimulating sodium reabsorption in the distal nephron and preventing pressure natriuresis

The Journal of Clinical Endocrinology and Metabolism
G JohannssonHans Herlitz

Abstract

Although sodium retention and volume expansion occur during GH administration, blood pressure is decreased or unchanged. The aim was to study the effect of short- and long-term GH replacement in adults on sodium balance, renal hemodynamics, and blood pressure. Ten adults with severe GH deficiency were included into a 7-d, randomized, placebo-controlled, cross-over trial followed by 12 months of open GH replacement. All measurements were performed under metabolic ward conditions. Extracellular water (ECW) was determined using multifrequency bioelectrical impedance analysis. Renal plasma flow and glomerular filtration rate were assessed using renal paraminohippurate and Cr(51) EDTA clearances, respectively. Renal tubular sodium reabsorption was assessed using lithium clearance. Plasma renin activity (PRA), plasma concentrations of angiotensin II, aldosterone, atrial natriuretic peptides and brain natriuretic peptides (BNP) and 24-h urinary norepinephrine excretion were measured. Seven days of GH treatment decreased urinary sodium excretion. Lithium clearance as a marker of proximal renal tubular sodium reabsorption was unaffected by GH treatment. ECW was increased after both short- and long-term treatment. This increase was inver...Continue Reading

References

Mar 15, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·A M KappelgaardJ Giese
Apr 1, 1991·The Journal of Clinical Endocrinology and Metabolism·J MøllerJ S Christiansen
Sep 1, 1988·The American Journal of Physiology·B L Blazer-Yost, M Cox
Jun 3, 1989·Lancet·J O JørgensenJ S Christiansen
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·H P GulerE R Froesch
Mar 1, 1989·Kidney International·R HirschbergJ D Kopple
Apr 1, 1985·Clinical Science·J J Morton, D J Webb
Sep 1, 1985·Journal of the Autonomic Nervous System·S F Hobbs, E K Potter
Jan 1, 1972·The Journal of Clinical Endocrinology and Metabolism·J P CainR G Dluhy
Mar 1, 1980·Kidney International·F G KnoxJ C Strand
Jun 1, 1982·Metabolism: Clinical and Experimental·A GangulyC C Johnston
Aug 1, 1982·Acta Endocrinologica·B E Karlberg, A M Ottosson
May 1, 1994·European Journal of Endocrinology·S A BeshyahD G Johnston
Mar 1, 1994·Clinical Endocrinology·K CaidahlB A Bengtsson
Feb 1, 1993·The Journal of Clinical Endocrinology and Metabolism·B A BengtssonO G Isaksson
Jan 1, 1997·Physiological Reviews·G F DiBona, U C Kopp
Dec 31, 1997·Biochemical Pharmacology·H KobayashiA Wada
Jul 31, 1998·The New England Journal of Medicine·E R LevinW K Samson
Jul 1, 1954·The Journal of Clinical Investigation·D IKKOSB SJOGREN
Mar 1, 1956·Acta Endocrinologica·D IKKOSR LUFT
May 1, 1964·Acta Endocrinologica·T FALKHEDEN, B SJOEGREN

❮ Previous
Next ❯

Citations

Nov 9, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Charlotte Hadtstein, Franz Schaefer
Nov 22, 2011·Annales d'endocrinologie·Solange GrunenwaldPhilippe Caron
Jun 29, 2015·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Kirstine Stochholm, Gudmundur Johannsson
Aug 16, 2015·Advances in Medical Sciences·Maria Roszkowska-Blaim, Piotr Skrzypczyk
Apr 5, 2016·Lancet·Claire E HighamStephen M Shalet
Mar 13, 2014·JPEN. Journal of Parenteral and Enteral Nutrition·Palle B Jeppesen
Sep 6, 2007·Endocrine Reviews·James GibneyPeter H Sönksen
Oct 26, 2006·American Journal of Physiology. Renal Physiology·Henrik DimkeSebastian Frische
May 1, 2013·Nature Reviews. Endocrinology·Atil Y Kargi, George R Merriam
Sep 6, 2019·GeroScience·Gabriela ColonMichal M Masternak
May 6, 2004·The Journal of Clinical Endocrinology and Metabolism·Patrick MaisonUNKNOWN Metaanalysis of Blinded, Randomized, Placebo-Controlled Trials
Apr 22, 2011·The Journal of Clinical Endocrinology and Metabolism·Peter KamenickyPhilippe Chanson
Jul 28, 2017·Frontiers in Medicine·Dhanunjay MukhiAnil Kumar Pasupulati
Feb 18, 2004·Journal of Endocrinological Investigation·J SvenssonB A Bengtsson
Aug 19, 2009·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·Koji MoriyaYouichi Kawaji
Jul 17, 2012·Scandinavian Journal of Clinical and Laboratory Investigation·Damien GrusonDominique Maiter
Mar 23, 2018·International Journal of Molecular Sciences·Juan J DíezFernando Cordido
Jul 19, 2005·Journal of Animal Science·N R Adams, J R Briegel
Feb 9, 2012·Cardiology in Review·Christopher R PalmeiroIrene A Weiss
Aug 4, 2021·The Journal of Clinical Endocrinology and Metabolism·Daniela EspositoDaniel S Olsson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.