GH replacement in hypopituitarism improves lipid profile and quality of life independently of changes in obesity variables

European Journal of Endocrinology
Pascale AbramsRoger Abs

Abstract

GH deficiency (GHD) in adults is characterized by elevated body mass index (BMI), increased waist girth (WG) and increased fat mass (FM). Information about how these indicators of obesity affect the lipid profile and quality of life (QoL) of GHD subjects is scarce. It is also unclear how changes in these indicators brought about by GH replacement influence lipids and QoL. Adult GHD subjects from the Pfizer International Metabolic Database were grouped according to BMI (n=291 with BMI <25 kg/m(2), n=372 with BMI 25-30 kg/m(2), n=279 with BMI >30 kg/m(2)), WG (n=508 with normal WG, n=434 with increased WG) and FM (n=357) and according to changes in these variables after 1 year of GH replacement. Serum IGF-I concentrations, lipid concentrations and QoL using the QoL Assessment of GHD in Adults questionnaire were assessed at baseline and after 1 year of treatment. At baseline, total and low-density lipoprotein (LDL) cholesterol were similarly elevated in the BMI and WG groups, but high-density lipoprotein (HDL) cholesterol decreased and triglycerides increased with increasing BMI and WG. QoL was progressively poorer with increasing BMI and WG. After 1 year of GH replacement, total and LDL cholesterol and QoL improved in all BMI, WG...Continue Reading

Citations

May 11, 2012·Journal of Pediatric Endocrinology & Metabolism : JPEM·Hugo L FideleffHugo R Boquete
Feb 24, 2015·Health & Social Care in the Community·Debbie HorsfallPenny Antonopoulos
Jun 26, 2012·Maturitas·Marianna AntonopoulouJocelyne G Karam
May 9, 2012·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Maria Claudia Peixoto CenciFlávia Lúcia Conceição
Jul 5, 2017·Journal of Pediatric Endocrinology & Metabolism : JPEM·Juliane RothermelThomas Reinehr
Jan 18, 2013·Journal of Neurotrauma·Odile Kozlowski MoreauMarc Rousseaux
Dec 15, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity·Omar Ali, David Wyatt
Apr 4, 2014·The Journal of Clinical Endocrinology and Metabolism·Nicholas A TritosBeverly M K Biller

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