GH3-Mediated Auxin Conjugation Can Result in Either Transient or Oscillatory Transcriptional Auxin Responses

Bulletin of Mathematical Biology
Nathan MellorJohn King

Abstract

The conjugation of the phytohormone auxin to amino acids via members of the gene family GH3 is an important component in the auxin-degradation pathway in the model plant species Arabidopsis thaliana, as well as many other plant species. Since the GH3 genes are themselves up-regulated in response to auxin, providing a negative feedback on intracellular auxin levels, it is hypothesised that the GH3s have a role in auxin homoeostasis. To investigate this, we develop a mathematical model of auxin signalling and response that includes the auxin-inducible negative feedback from GH3 on the rate of auxin degradation. In addition, we include a positive feedback on the rate of auxin input via the auxin influx transporter LAX3, shown previously to be expressed in response to auxin and to have an important role during lateral root emergence. In the absence of the LAX3 positive feedback, we show that the GH3 negative feedback suffices to generate a transient transcriptional response to auxin in the shape of damped oscillations of the model system. When LAX3 positive feedback is present, sustained oscillations of the system are possible. Using steady-state analyses, we identify and discuss key parameters affecting the oscillatory behaviour o...Continue Reading

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Dec 3, 2014·Journal of Theoretical Biology·Nathan MellorJohn King

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Citations

Jan 10, 2017·Frontiers in Plant Science·Alejandro Morales-Tapia, Alfredo Cruz-Ramírez
May 21, 2020·Journal of Experimental Botany·Tomas RibbaJosé Antonio O'Brien
Nov 6, 2018·Developmental Biology·Kirsten Ten Tusscher

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