PMID: 11932557Apr 5, 2002Paper

Ghostbursting: a novel neuronal burst mechanism

Journal of Computational Neuroscience
B DoironLeonard Maler

Abstract

Pyramidal cells in the electrosensory lateral line lobe (ELL) of weakly electric fish have been observed to produce high-frequency burst discharge with constant depolarizing current (Turner et al., 1994). We present a two-compartment model of an ELL pyramidal cell that produces burst discharges similar to those seen in experiments. The burst mechanism involves a slowly changing interaction between the somatic and dendritic action potentials. Burst termination occurs when the trajectory of the system is reinjected in phase space near the "ghost" of a saddle-node bifurcation of fixed points. The burst trajectory reinjection is studied using quasi-static bifurcation theory, that shows a period doubling transition in the fast subsystem as the cause of burst termination. As the applied depolarization is increased, the model exhibits first resting, then tonic firing, and finally chaotic bursting behavior, in contrast with many other burst models. The transition between tonic firing and burst firing is due to a saddle-node bifurcation of limit cycles. Analysis of this bifurcation shows that the route to chaos in these neurons is type I intermittency, and we present experimental analysis of ELL pyramidal cell burst trains that support ...Continue Reading

Citations

Feb 26, 2003·Nature Neuroscience·Fabrizio Gabbiani
Jul 7, 2007·Journal of Neurophysiology·Lee D EllisMaurice J Chacron
Dec 1, 2007·Neural Computation·Natalia ToporikovaRichard Bertram
Nov 10, 2015·Nature Communications·Stephen E ClarkeLeonard Maler
Apr 12, 2016·Communicative & Integrative Biology·Hojeong Kim, C J Heckman
Dec 9, 2003·Nature Reviews. Neuroscience·Rüdiger Krahe, Fabrizio Gabbiani
Mar 28, 2007·Journal of Computational Neuroscience·Takashi TakekawaTomoki Fukai
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Jan 20, 2018·Physical Review. E·Jens Doose, Benjamin Lindner
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