PMID: 16508225Mar 2, 2006Paper

Ghrelin, a novel growth hormone-releasing peptide, in the treatment of cardiopulmonary-associated cachexia

Internal Medicine
Noritoshi NagayaKenji Kangawa

Abstract

Ghrelin is a novel growth hormone (GH)-releasing peptide, isolated from the stomach, which has been identified as an endogenous ligand for GH secretagogue receptor. The discovery of ghrelin indicates that the release of GH from the pituitary might be regulated not only by hypothalamic GH-releasing hormone, but also by ghrelin derived from the stomach. This peptide also stimulates food intake and induces adiposity through GH-independent mechanisms. In addition, ghrelin acts directly on the central nervous system to decrease sympathetic nerve activity. Thus, ghrelin plays important roles for maintaining GH release and energy homeostasis. Repeated administration of ghrelin improves body composition, muscle wasting, functional capacity, and sympathetic augmentation in cachectic patients with heart failure or chronic obstructive pulmonary disease. These results suggest that ghrelin has anti-cachectic effects through GH-dependent and independent mechanisms. Thus, administration of ghrelin may be a new therapeutic strategy for the treatment of cardiopulmonary-associated cachexia.

References

Nov 1, 1992·Journal of Gastroenterology and Hepatology·F I ToveyM Hobsley
Feb 15, 1992·The Biochemical Journal·S J FullerP H Sugden
Jul 26, 1990·The New England Journal of Medicine·B LevineM Packer
Jul 18, 1995·Proceedings of the National Academy of Sciences of the United States of America·A A PatchettG Hickey
Dec 8, 1994·The New England Journal of Medicine·G W Dec, V Fuster
Jun 11, 1993·Science·R G SmithF Judith
Mar 28, 1996·The New England Journal of Medicine·S FazioL Saccà
Mar 1, 1996·American Journal of Respiratory and Critical Care Medicine·K Gray-DonaldJ G Martin
Jan 1, 1997·Annual Review of Physiology·G SachsC Prinz
Mar 21, 1998·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·V Locatelli, A Torsello
Dec 19, 1998·European Heart Journal·J IsgaardB A Bengtsson
Dec 10, 1999·American Journal of Respiratory and Critical Care Medicine·C LandboT P Almdal
Oct 12, 2000·Biochemical and Biophysical Research Communications·Y MasudaK Kangawa
Nov 1, 2000·Nature·M TschöpM L Heiman
Jan 3, 2001·The Journal of Clinical Endocrinology and Metabolism·K TakayaK Nakao
Feb 13, 2001·Biochemical and Biophysical Research Communications·H HosodaK Kangawa
Feb 13, 2001·Biochemical and Biophysical Research Communications·Y DateS Matsukura
Feb 24, 2001·Nature·M NakazatoS Matsukura
Mar 13, 2001·Biochemical and Biophysical Research Communications·K ToshinaiS Matsukura
Apr 6, 2001·Diabetes·M TschöpM L Heiman
Apr 11, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·N NagayaK Kangawa
Apr 27, 2001·Endocrine·J SvenssonJ O Jansson
Apr 27, 2001·Endocrine·R BaldelliF F Casanueva
Sep 11, 2001·The Journal of Clinical Endocrinology and Metabolism·E RavussinM L Heiman
Sep 11, 2001·The Journal of Clinical Endocrinology and Metabolism·Y HatayaK Nakao
Dec 12, 2001·The Journal of Clinical Endocrinology and Metabolism·N NagayaK Kangawa
May 7, 2002·Scandinavian Journal of Gastroenterology·D Lehto-AxteliusR Håkanson
May 15, 2002·European Journal of Pharmacology·Giampiero MuccioliEzio Ghigo
May 23, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·L TrudelP Poitras
May 22, 2002·Journal of Cardiovascular Pharmacology·Hiroyuki OkumuraKenji Kangawa

❮ Previous
Next ❯

Citations

Mar 21, 2013·Journal of Gastroenterology·Hajime SuzukiAkio Inui
Jul 4, 2012·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·J M ArgilésS Busquets
Mar 6, 2009·Journal of Tropical Pediatrics·Manal E KandilMaha Rasheed
Aug 14, 2008·The Journal of Clinical Endocrinology and Metabolism·Remberto C PauloJohannes D Veldhuis
Feb 5, 2011·Journal of Endocrinological Investigation·G AngelidisP Georgoulias
Aug 28, 2010·International Journal of Peptides·Johannes D Veldhuis, Cyril Y Bowers
Aug 28, 2010·International Journal of Peptides·Manfredi TesauroCarmine Cardillo
Jun 24, 2015·The Journal of Endocrinology·Manami OyaTakashi Tsuboi
Apr 9, 2011·Journal of Cachexia, Sarcopenia and Muscle·Takashi Akamizu, Kenji Kangawa
Apr 9, 2011·Journal of Cachexia, Sarcopenia and Muscle·Timo D MüllerMatthias H Tschöp
Dec 17, 2014·Nutrition and Cancer·Patrizia MondelloVincenzo Pitini
Feb 27, 2009·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Steven P DunnOrly Vardeny
Jan 12, 2017·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Yu BaiZhiqiang Zhao
Apr 25, 2007·Annals of Medicine·Susie C HigginsMárta Korbonits
May 8, 2007·Vascular Pharmacology·Daniela Z DimitrovaDessislava B Duridanova
Aug 19, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Carine De Vriese, Christine Delporte
Sep 26, 2007·Nature Clinical Practice. Endocrinology & Metabolism·Petra WiedmerMatthias H Tschöp
Aug 8, 2008·Current Opinion in Supportive and Palliative Care·Mitja LainscakStefan D Anker
Jun 11, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Mayra M Kamiji, Akio Inui
Sep 11, 2009·Current Opinion in Clinical Nutrition and Metabolic Care·John E Morley
Apr 7, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Takashi Akamizu, Kenji Kangawa
Mar 14, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michi YukawaTami Wolden-Hanson
Apr 18, 2008·World Journal of Gastroenterology : WJG·Hai-Tao WangHai-Xin Qian
Jun 27, 2009·European Journal of Heart Failure·Lars H LundDonna M Mancini
Jul 10, 2007·Journal of the American Medical Directors Association·Shing-Shing YehMichael W Schuster

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.