Ghrelin ameliorates catabolic conditions and respiratory dysfunction in a chronic obstructive pulmonary disease model of chronic cigarette smoke-exposed rats

European Journal of Pharmacology
Yoshiyuki KamiideToshihiko Yada

Abstract

Cigarette smoking, which is a well-known major risk factor for chronic obstructive pulmonary disease (COPD), causes both pulmonary and extrapulmonary abnormalities. Ghrelin is a gastric peptide that regulates energy homeostasis. In the present study, we investigated the effects of ghrelin on the catabolic changes, respiratory function and emphysema in an animal model of COPD induced by chronic exposure to cigarette smoke. Rats were exposed to cigarette smoke, and they were administered human ghrelin (0.1 or 1 mg/kg, subcutaneous, twice daily) for 12 weeks. Compared with air-exposed rats, body weight gain, food intake, food efficiency, tidal volume, peak expiratory flow rate, and forced expiratory volume at 100 ms were significantly lower, while functional residual capacity, lung capacity, and neutrophils in bronchoalveolar lavage fluid were significantly higher in cigarette smoke-exposed rats. These indicated that the systemic abnormalities associated with COPD developed after the exposure to cigarette smoke. Ghrelin significantly and dose-dependently increased the body weight gain and food efficiency in cigarette smoke-exposed rats. In ghrelin-treated rats, skeletal muscle strength, which tended to be lowered by cigarette smok...Continue Reading

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Citations

Apr 12, 2017·International Journal of Molecular Sciences·Gustav ColldénTimo D Müller
Mar 1, 2018·Chronic Respiratory Disease·Xue ZhangLei Chen
Sep 22, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Yusuke TakahashiMasafumi Kawamura
Nov 5, 2017·Respiratory Research·Nazareth de Novaes RochaPatricia Rieken Macedo Rocco
Sep 7, 2019·International Journal of Molecular Sciences·Botond SzucsJanos T Varga

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