Ghrelin and acyl ghrelin levels are associated with inflammatory and nutritional markers and with cardiac and vascular dysfunction parameters in hemodialysis patients

International Urology and Nephrology
Crina Claudia RusuIna Maria Kacso

Abstract

Exogenous ghrelin is associated with cardiovascular protection in experimental and human studies. Nevertheless ESRD patients have increased ghrelin levels and severe cardiovascular comorbidities. This study aims to elucidate the metabolic factors influencing endogenous ghrelin/acyl ghrelin levels and to analyze the relation between endogenous ghrelin/acyl ghrelin levels and cardiac and vascular function markers in hemodialysis patients. The cross-sectional study was conducted in hemodialysis patients (n = 88); 50 of them were men, mean age 61.1 ± 13.5 years, 17% had diabetes. We assessed nutritional and inflammatory status and analyzed the determinants of ghrelin/acyl ghrelin and their relation with cardiac and vascular function. Ghrelin is correlated with IL-1β (r = 0.88, p < 0.0001), triglycerides, total cholesterol (TC), and Kt/V. IL-1β is the strongest predictor of ghrelin levels (p < 0.0001). Acyl ghrelin is correlated with TC (r = 0.36, p = 0.001), LDL-cholesterol, serum bicarbonate, body mass index. TC is the strongest predictor for acyl ghrelin levels (p = 0.038). Patients with high ghrelin levels had significantly decreased nitroglycerin-mediated dilation (p = 0.05) and higher IL-1β levels (p < 0.001); increased NT-pro...Continue Reading

References

Feb 13, 2001·Biochemical and Biophysical Research Communications·H HosodaK Kangawa
Jan 23, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ernesto Rodriguez AyalaPeter Stenvinkel
Jun 10, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Miguel Pérez-FontánJesús García-Buela
Oct 16, 2004·The Journal of Clinical Endocrinology and Metabolism·Takashi AkamizuKenji Kangawa
Dec 17, 2004·The New England Journal of Medicine·Jennifer K PaiEric B Rimm
Sep 27, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Susan VickeryEdmund J Lamb
Apr 6, 2006·Clinical Chemistry·Demosthenes BourosAsterios Kukuvitis
Sep 5, 2006·Atherosclerosis·Fabio RossiVittorio Santiemma
Apr 13, 2007·The New England Journal of Medicine·Claus M LarsenMarc Y Donath
Jun 9, 2007·American Journal of Nephrology·Maurizio MuscaritoliFilippo Rossi Fanelli
Aug 2, 2007·The Journal of Clinical Endocrinology and Metabolism·Greisa VilaMartin Clodi
Sep 22, 2007·Metabolism: Clinical and Experimental·Eric ToussirotDaniel Wendling
Nov 27, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Sangeetha SatyanRajiv Agarwal
Feb 7, 2008·The Journal of Endocrinology·Lisa D MadisonDaniel L Marks
Mar 21, 2008·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Rubin I CohenSubani Chandra
Nov 17, 2009·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Denise MafraDenis Fouque
Dec 19, 2009·Nutrition·Denise MafraD Fouque
Dec 30, 2009·Pharmacological Reviews·Chih-Yen ChenAkio Inui
Aug 20, 2010·International Journal of Peptides·Wai W Cheung, Robert H Mak
Nov 3, 2011·Archives of Cardiovascular Diseases·Brad S DaltonJeff S Coombes
Mar 23, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Tatsuya MaruhashiYukihito Higashi
Jul 3, 2013·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Amanda de Faria BarrosDenise Mafra
Jul 12, 2013·International Journal of Nephrology and Renovascular Disease·Hernán TrimarchiMariana Dicugno
Feb 11, 2014·Archives of Medical Research·Yanbo ChenChun-hua Zhao
Dec 17, 2014·Pharmacology Research & Perspectives·Cheng-Kun DuMikiyasu Shirai
Dec 30, 2014·Heart Views : the Official Journal of the Gulf Heart Association·Mahalaqua Nazli KhatibDilip Gode
Feb 26, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Magid A FahimJonathan C Craig
Apr 22, 2015·Annals of Nutrition & Metabolism·Anne KoopmannFalk Kiefer

❮ Previous
Next ❯

Citations

Oct 3, 2018·International Journal of Molecular Sciences·Żaneta Kimber-TrojnarBożena Leszczyńska-Gorzelak
Mar 25, 2020·International Journal of Nephrology·Jacques DucrosLydia Foucan
Oct 8, 2020·Heart Failure Reviews·Shreyasi Gupta, Arkadeep Mitra

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Related Papers

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia
Moncef El M'barki KadiriZouhir Oualim
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
J BorawskiM Mysliwiec
© 2022 Meta ULC. All rights reserved