Ghrelin and measures of satiety are altered in polycystic ovary syndrome but not differentially affected by diet composition

The Journal of Clinical Endocrinology and Metabolism
Lisa J MoranR J Norman

Abstract

Polycystic ovary syndrome (PCOS) is a common endocrine condition in women of reproductive age associated with obesity. It may involve dysregulation of ghrelin, a hormone implicated in appetite regulation. The effect of diet composition on ghrelin is unclear. Overweight women with and without PCOS were randomized to a high-protein (40% carbohydrate, 30% protein; 10 PCOS, six non-PCOS) or standard protein diet (55% carbohydrate, 15% protein; 10 PCOS, six non-PCOS) for 12 wk of energy restriction and 4 wk of weight maintenance. Diet composition had no effect on fasting or postprandial ghrelin or measures of satiety. Non-PCOS subjects had a 70% higher fasting baseline ghrelin (P = 0.011), greater increase in fasting ghrelin (57.5 vs. 34.0%, P = 0.033), and greater maximal decrease in postprandial ghrelin after weight loss (-144.1 +/- 58.4 vs. -28.9 +/- 14.2 pg/ml, P = 0.02) than subjects with PCOS. Subjects with PCOS were less satiated (P = 0.001) and more hungry (P = 0.007) after a test meal at wk 0 and 16 than subjects without PCOS. Appetite regulation, as measured by subjective short-term hunger and satiety and ghrelin homeostasis, may be impaired in PCOS.

Citations

Nov 5, 2008·Nature Clinical Practice. Endocrinology & Metabolism·Manuel Tena-Sempere
Aug 24, 2005·The British Journal of Nutrition·Kate Marsh, Jennie Brand-Miller
Apr 1, 2007·Obesity Management·Susan Sam
May 4, 2005·Clinical Evidence·Hesham Al-Inany
Aug 28, 2010·International Journal of Peptides·Chrysi KoliakiNicholas Katsilambros
Jun 9, 2005·Gynecologic and Obstetric Investigation·Jana VrbíkováLuboslav Stárka
Mar 26, 2008·European Journal of Endocrinology·Thomas M BarberJohn A H Wass
Nov 1, 2013·Human Reproduction Update·Alexander N ComninosWaljit S Dhillo
Dec 14, 2007·Journal of Endocrinological Investigation·D MicicF F Casanueva
Jan 1, 2007·Women's Health·Siew S LimRobert J Norman
Aug 26, 2009·Women's Health·Angelica Lindén Hirschberg
Dec 30, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Sahruh TurkmenYucel Cengiz
Nov 26, 2008·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Mitko MitkovMaria Orbetzova
Jun 2, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Mariana K ToscaniPoli Maria Spritzer
Jul 10, 2007·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Wojciech BikBoguslawa Baranowska
Feb 10, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Dorte Glintborg, Marianne Andersen
Apr 5, 2011·Journal of Pediatric and Adolescent Gynecology·Tolga Altuğ ŞenMehmet Yılmazer
Apr 2, 2011·Molecular and Cellular Endocrinology·Andrea RepaciRenato Pasquali
Jun 12, 2010·Journal of Pediatric and Adolescent Gynecology·I T OzgenY Aliyazicıoglu
Jan 26, 2010·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Dimitrios PanidisEvanthia Diamanti-Kandarakis
Jun 13, 2009·Physiology & Behavior·Siew S LimManny Noakes
Oct 22, 2008·The Journal of Obstetrics and Gynaecology Research·Aysun BideciPeyami Cinaz
Aug 5, 2006·Clinical Endocrinology·T M BarberS Franks
Sep 16, 2006·BJOG : an International Journal of Obstetrics and Gynaecology·L E P Wood
Sep 24, 2004·Best Practice & Research. Clinical Obstetrics & Gynaecology·L Moran, R J Norman
May 2, 2006·Fertility and Sterility·Renato Pasquali
Feb 1, 2014·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·A M dos S RodriguesA V M Ferreira
Jul 1, 2015·International Journal of Endocrinology·Dinka Pavicic BaldaniRoya Ougouag
Sep 8, 2016·European Journal of Endocrinology·Dorte Glintborg, Marianne Andersen
Jun 2, 2017·Journal of Women's Health·Leah BrennanLisa Moran
Jun 10, 2011·Journal of Pharmacy Practice·Kristin Nadine Whitaker
Sep 7, 2017·Reproductive Sciences·Romualdi DanielaLanzone Antonio
Jul 24, 2018·Nutrition Research Reviews·Luigi BarreaSilvia Savastano
Mar 10, 2005·American Journal of Physiology. Endocrinology and Metabolism·Madhusmita MisraAnne Klibanski
Sep 25, 2017·Endocrine Reviews·Luba SominskySarah J Spencer
Oct 16, 2012·Endocrine Reviews·Evanthia Diamanti-Kandarakis, Andrea Dunaif

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