Ghrelin and obestatin in thyroid gland - immunohistochemical expression in nodular goiter, papillary and medullary cancer

Folia Histochemica Et Cytobiologica
Edyta GurgulMarek Ruchala

Abstract

Previous studies analyzing ghrelin and obestatin expression in thyroid gland tissue are not unanimous and are mostly related to ghrelin. The role of ghrelin and obestatin in the thyroid gland appears very interesting due to their probable involvement in cell proliferation. Furthermore, since the thyroid gland is associated with the maintenance of energy balance, the relationship between ghrelin, obestatin and thyroid function is worthy of consideration. The aim of the study was to assess ghrelin and obestatin immunocytochemical expression in nodular goiter (NG), papillary cancer (PTC) and medullary cancer (MTC). Analyzed samples included 9 cases of NG, 8 cases of PTC and 11 cases of MTC. The analysis of ghrelin and obestatin expression was performed by use of the immunohistochemical (IHC) EnVision system and evaluated with filter HSV software (quantitative morphometric analysis). Quantitative ghrelin expression in MTC cells was higher than in NG (p = 0.013) and correlated negatively with the size of the tumor (r= -0.829, p < 0.05). We did not observe any differences in ghrelin expression neither between MTC and PTC nor between NG and PTC. Obestatin immunoexpression pattern in all analyzed specimens was irregular and poorly acce...Continue Reading

Citations

Oct 5, 2017·Archives of Endocrinology and Metabolism·Bekir UcanErman Cakal
Jun 5, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Yanbo ChenLianqun Cui
Jul 17, 2018·Current Medicinal Chemistry·Theodora TzanavariStamatios Theocharis
Jan 26, 2017·Frontiers in Oncology·CheukMan Cherie AuKristy A Brown
Jun 11, 2020·European Journal of Clinical Nutrition·Chiara MelePaolo Marzullo
Dec 3, 2017·Clinical Endocrinology·Ariadna Zybek-KocikMarek Ruchała
Oct 3, 2018·World Journal of Gastroenterology : WJG·Aldona KasprzakWitold Szaflarski

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