Ghrelin as a novel therapy for radiation combined injury.

Molecular Medicine
Asha JacobPing Wang

Abstract

The threat of nuclear terrorism has led to growing worldwide concern about exposure to radiation. Acute radiation syndrome, or radiation sickness, develops after whole-body or a partial-body irradiation with a high dose of radiation. In the terrorist radiation exposure scenario, however, radiation victims likely suffer from additional injuries such as trauma, burns, wounds or sepsis. Thus, high-dose radiation injuries and appropriate therapeutic interventions must be studied. Despite advances in our understanding of the pathophysiology of radiation injury, very little information is available on the therapeutic approaches to radiation combined injury. In this review, we describe briefly the pathological consequences of ionizing radiation and provide an overview of the animal models of radiation combined injury. We highlight the combined radiation and sepsis model we recently established and suggest the use of ghrelin, a novel gastrointestinal hormone, as a potential therapy for radiation combined injury.

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Citations

Nov 9, 2012·Journal of Leukocyte Biology·Monowar AzizPing Wang
Mar 27, 2019·Cell & Bioscience·Juliann G Kiang, Ayodele O Olabisi
Nov 6, 2010·Clinical Endocrinology·Matthew Blatnik, Catherine I Soderstrom
Mar 9, 2012·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Akihisa MatsudaPing Wang
Mar 22, 2014·Drug Development Research·Karin E ThompsonCharles R Yates
Aug 9, 2016·PloS One·Paridhi GuptaRadha K Maheshwari
Aug 5, 2017·International Journal of Molecular Sciences·Nikolai V Gorbunov, Juliann G Kiang
Jan 25, 2017·Radiation Research·Vlado AntonicZeljko Vujaskovic
Feb 20, 2021·Frontiers in Pharmacology·Juliann G KiangSuping Jiang

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