Ghrelin attenuates vascular calcification in diabetic patients with amputation

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Suining XuZhongqun Wang

Abstract

Vascular calcification is established to be a critical factor in diabetes mellitus, which causes cardiovascular and amputation complication of diabetic patients. OPG/RANKL/RANK axis serves as a regulatory role in vascular calcification. Ghrelin, an endogenous ligand of growth hormone secretagogue receptor (GHSR), has been reported to exhibit potent cardiovascular protective effects. However, the role of ghrelin in the regulation of diabetic vascular calcification is still elusive. Here, we reported the role of ghrelin and its relationship with OPG/RANKL/RANK system in patients with diabetic foot amputation. In vivo and in vitro investigations were performed. Sixty type 2 diabetic patients with foot amputation were enrolled in vivo investigation, and they were divided into three groups through Doppler ultrasound: mild stenosis group (n=20), moderate stenosis group (n=20), and severe stenosis/occlusion group (n=20). Morphological analysis results showed diffused calcium depositions in the anterior tibial artery of diabetic amputees. Compared with the mild and moderate stenosis group, the severe stenosis/occlusion group had more spotty calcium depositions in atherosclerotic plaques. Western blot analysis indicated the expressions ...Continue Reading

Citations

Jan 13, 2018·Frontiers in Endocrinology·Joshua P H NealeDaryl O Schwenke
Apr 25, 2019·Cell Biochemistry and Function·Nabil El ZeinWissam H Faour
Apr 18, 2020·Alimentary Pharmacology & Therapeutics·Michael CamilleriAlexandru Iacob
Jan 4, 2019·Acta Diabetologica·Zhen SunLili Zhang
Jan 12, 2021·Bioscience Reports·Ming-Jie YuanPeng Zhong

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