Ghrelin Derangements in Idiopathic Dilated Cardiomyopathy: Impact of Myocardial Disease Duration and Left Ventricular Ejection Fraction

Journal of Clinical Medicine
Aneta AleksovaGianfranco Sinagra

Abstract

Ghrelin may exert positive effects on cardiac structure and function in heart failure (HF) patients. We assessed ghrelin levels in 266 dilated cardiomyopathy (DCM) patients and in 200 age, gender and body mass index (BMI) matched controls. Further, we evaluated the expression of ghrelin and growth hormone secretagogue-receptor (GHSR) in the myocardium of 41 DCM patients and in 11 controls. DCM patients had significantly lower levels of total, acylated and unacylated ghrelin when compared to controls (p < 0.05 for all). In controls, we observed a negative correlation of ghrelin with age, male gender and BMI. These correlations were lost in the DCM group, except for male gender. Total ghrelin was higher in patients with more recent diagnosis when compared to patients with longer duration of the DCM (p = 0.033). Further, total ghrelin was higher in patients with lower left ventricular systolic function (<40% LVEF, vs. 40% ≤ LVEF < 49% vs. LVEF ≥ 50%: 480.8, vs. 429.7, vs. 329.5 pg/mL, respectively, p = 0.05). Ghrelin prepropeptide was expressed more in DCM patients than in controls (p = 0.0293) while GHSR was expressed less in DCM patients (p < 0.001). Furthermore, ghrelin showed an inverse correlation with its receptor (= -0.40...Continue Reading

References

Sep 1, 1993·International Journal of Cardiology·J E SandersonD Gatei
Apr 11, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·N NagayaK Kangawa
Dec 12, 2001·The Journal of Clinical Endocrinology and Metabolism·N NagayaK Kangawa
Apr 12, 2003·Current Opinion in Pharmacology·Noritoshi Nagaya, Kenji Kangawa
May 26, 2004·Cardiovascular Research·María J IglesiasFrancisca Lago
Jan 11, 2007·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M D KlokM L Drent
Jun 27, 2009·European Journal of Heart Failure·Lars H LundDonna M Mancini
Jun 8, 2010·European Journal of Heart Failure·Michele MorettiGianfranco Sinagra
Jun 8, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Giuseppe AlloattiGiampiero Muccioli
Apr 9, 2011·Journal of Cachexia, Sarcopenia and Muscle·Timo D MüllerMatthias H Tschöp
Aug 30, 2012·Nature Methods·Caroline A SchneiderKevin W Eliceiri
Feb 11, 2014·Archives of Medical Research·Yanbo ChenChun-hua Zhao
Jun 25, 2014·Hypertension·Yuanjie MaoIchiro Kishimoto
Dec 17, 2014·Pharmacology Research & Perspectives·Cheng-Kun DuMikiyasu Shirai
May 12, 2015·International Journal of Endocrinology·Elia AngelinoNicoletta Filigheddu
Jul 27, 2017·Journal of Cellular and Molecular Medicine·Claudia PennaRiccarda Granata
Feb 17, 2018·Journal of the Endocrine Society·Rebecca SullivanSavita Dhanvantari

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
Assay
biopsies

Software Mentioned

SPSS
R
ImageJ

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.