Ghrelin, des-acyl ghrelin and nesfatin-1 in gastric X/A-like cells: role as regulators of food intake and body weight.

Peptides
Andreas StengelYvette Taché

Abstract

Numerous peptides released from endocrine cells in the intestinal mucosa were established early on to be involved in the physiological regulation of food intake with a prominent role in termination of food ingestion when nutrients pass along the intestinal tract. Recently, peptides released from X/A-like endocrine cells of the gastric oxyntic mucosa were recognized as additional key players in the regulation of feeding and energy expenditure. Gastric X/A-like cells release the octanoylated peptide, ghrelin, the only known peripherally produced hormone stimulating food intake through interaction with growth hormone secretagogue 1a receptor (GHS-R1a). Additionally, non-octanoylated (des-acyl) ghrelin present in the circulation at higher levels than ghrelin is currently discussed as potential modulator of food intake by opposing ghrelin's action independent from GHS-R1a although the functional significance remains to be established. Obestatin, a ghrelin-associated peptide was initially reported as anorexigenic modulator of ghrelin's orexigenic action. However, subsequent reports did not support this contention. Interesting is the recent identification of nesfatin-1, a peptide derived from the nucleobindin2 gene prominently express...Continue Reading

References

Aug 1, 1993·Gastroenterology·C PrinzG Sachs
Aug 1, 1997·Brain Research. Molecular Brain Research·X M GuanA D Howard
Sep 2, 1998·Nature·A BadoM J Lewin
Oct 31, 1998·Nature·J M Friedman, J L Halaas
Mar 4, 2000·Microscopy Research and Technique·C BordiG Ferraro
Apr 15, 2000·Nature·M W SchwartzD G Baskin
Nov 1, 2000·Nature·M TschöpM L Heiman
Feb 13, 2001·Biochemical and Biophysical Research Communications·H HosodaK Kangawa
Feb 24, 2001·Nature·M NakazatoS Matsukura
Sep 11, 2001·The Journal of Clinical Endocrinology and Metabolism·N HattoriC Inagaki
May 25, 2002·The New England Journal of Medicine·David E CummingsJonathan Q Purnell
Jul 2, 2002·Nature Medicine·David E CummingsDavid S Weigle
Jul 11, 2002·Histochemistry and Cell Biology·Guido RindiEnrico Solcia
Jul 20, 2002·The Journal of Pharmacology and Experimental Therapeutics·William A BanksMark L Heiman
Oct 18, 2002·Neuron·Clifford B SaperJoel K Elmquist
Nov 22, 2002·Biology of Reproduction·M L BarreiroM Tena-Sempere
Mar 5, 2003·Biochemical and Biophysical Research Communications·Mitsushi ShimadaMasamitsu Nakazato
Apr 3, 2004·Trends in Pharmacological Sciences·Birgitte Holst, Thue W Schwartz
Apr 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yuxiang SunRoy G Smith
Apr 20, 2004·Regulatory Peptides·Florian LipplVolker Schusdziarra
Apr 28, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M PerreaultA Stricker-Krongrad
May 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Katherine E WortleyMark W Sleeman
May 22, 2004·Annals of the New York Academy of Sciences·Guido RindiEnrico Solcia
Sep 24, 2004·The Journal of Biological Chemistry·Birgitte HolstThue W Schwartz
Oct 9, 2004·Endocrinology·Hiroyuki AriyasuKazuwa Nakao
Nov 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Tae Yong JeonMun Sup Sim
Nov 20, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Peter KobeltHubert Mönnikes

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Citations

Mar 26, 2013·Endocrine·Suleyman Aydin
Sep 26, 2013·Nature Reviews. Gastroenterology & Hepatology·John B FurnessBrid Callaghan
Jun 4, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Andreas StengelYvette Taché
Apr 24, 2012·Journal of Obesity·Christine Delporte
Aug 24, 2013·PloS One·Ziru LiWeizhen Zhang
Jul 5, 2013·International Journal of Endocrinology and Metabolism·Abbass Ghanbari NiakiHasan Bayat
Sep 8, 2011·Current Opinion in Gastroenterology·Mitchell L Schubert
Jan 2, 2014·Scientifica·Christine Delporte
Jan 1, 2012·ISRN Veterinary Science·R M Garcia-Garcia
May 21, 2014·Cell and Tissue Research·Hyun-Jung ChoJohn B Furness
Dec 1, 2011·Scandinavian Journal of Gastroenterology·Herbert F Helander, Lars Fändriks
Jan 8, 2013·Expert Opinion on Biological Therapy·Alessio MolfinoMaurizio Muscaritoli
Jan 17, 2016·General and Comparative Endocrinology·Juan Ignacio BertucciSuraj Unniappan
Jan 10, 2012·Neuropeptides·Artur PałaszGrzegorz Bajor
Aug 16, 2011·Medical Hypotheses·J F SaldanhaD Mafra
Feb 14, 2016·The International Journal of Neuroscience·Murteza CakirAtilla Topcu
Jun 30, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H HirayamaY Shimizu
Mar 27, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L WangY Taché
May 14, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A StengelY Taché
Dec 31, 2014·Endocrine·Thomas Reinehr, Christian L Roth
Apr 30, 2013·Appetite·James A KingMyra A Nimmo
Oct 27, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A J Page, S J Kentish
Jan 31, 2017·International Journal of Molecular Sciences·Ken HowickHarriët Schellekens
Dec 1, 2012·Balsaeng'gwa saengsig·Jinhee Kim, Hyunwon Yang
Dec 1, 2013·Balsaeng'gwa saengsig·Yiwa ChungHyunwon Yang
Nov 1, 2018·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Juan Ignacio BertucciLuis Fabián Canosa

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