Ghrelin in small-for-gestational age (SGA) newborn babies: a cross-sectional study

Clinical Endocrinology
Francisco Méndez-RamírezJuan Manuel Malacara

Abstract

Small-for-gestational newborn babies may have long-term metabolic consequences. Among the main hormones possibly involved in foetal growth regulation are the IGFs, IGFBPs and the recently described ghrelin. To examine the levels of desacyl-ghrelin, IGF-1, IGFBP-1 and IGFBP-3 in children Small-for-gestational age (SGA) and children adequate-for-gestational age (AGA). This was a cross-sectional and comparative study. We included 40 children SGA and 40 children AGA. Blood sample was taken a week after birth and measuring hormonal levels were done by ELISA. SGA babies had lower IGF-1, IGFBP-3 and leptin levels, but higher ghrelin and IGFBP-1 levels. Birth weight was associated independently with ghrelin and IGFBP-1 (negatively) and IGFBP-3 (positively). Ghrelin circulating levels were associated negative and independently with IGFBP-3 and triglycerides in the mother. We interpreted these findings to indicate that diminished body weight in newborns induce different adaptive signals, some of them mediated by IGF-1/IGFBP-3, ghrelin or by IGFBP-1. This regulation is congruent with the proposed role of ghrelin to adaptation to under-nutrition favouring lipid accumulation. CONCyTEG grant number 05-16-K117-028.

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Citations

Dec 7, 2011·European Journal of Endocrinology·Hamilcikan SahinYildiz Perk
Dec 20, 2008·European Journal of Endocrinology·Despina D Briana, Ariadne Malamitsi-Puchner
Sep 19, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Despina D Briana, Ariadne Malamitsi-Puchner
Jun 9, 2016·Journal of Pediatric Endocrinology & Metabolism : JPEM·Renata StawerskaAndrzej Lewiński
Feb 18, 2020·European Journal of Pediatrics·Elizabeth Soares da Silva MagalhãesMaria Elisabeth Lopes Moreira
Dec 3, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Umair SharihBarbara V Parilla

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