Ghrelin induces growth hormone secretion via a nitric oxide/cGMP signalling pathway

Journal of Neuroendocrinology
F Rodríguez-PachecoJ P Castaño

Abstract

The presence of ghrelin and its receptor, growth hormone (GH) secretagogue receptor, in the hypothalamus and pituitary, and its ability to stimulate GH release in vivo and in vitro, strongly support a significant role for this peptide in the control of somatotroph function. We previously demonstrated that ghrelin elicits GH secretion directly in somatotrophs by activating two major signalling cascades, which involve inositol phosphate and cAMP. In as much as nitric oxide (NO) and its mediator cGMP have been recently shown to contribute substantially to the response of somatotrophs to key regulatory hormones, including GH-releasing hormone, somatostatin and leptin, we investigated the possible role of this signalling pathway in ghrelin-induced GH release in vitro. Accordingly, cultures of pituitary cells from prepuberal female pigs were challenged with ghrelin (10(-8) m, 30 min) in the absence or presence of activators or blockers of key steps of the NO synthase (NOS)/NO/guanylate cyclase (GC)/cGMP route and GH secretion was measured. Two distinct activators of the NO route, S-nitroso-N-acetylpenicillamine (SNAP) (5 x 10(-4) m) and L-arginine methyl ester hydrochloride (L-AME) (10(-3) m), comparably stimulated GH secretion when ...Continue Reading

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Citations

May 27, 2011·Neuroscience Bulletin·Ming-Yu Jiang, De-Pei Cai
Feb 18, 2010·PloS One·Guillaume OsterstockPierre-François Méry
May 30, 2012·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S C F OlintoM T Nunes
May 14, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·Eugenia Mercedes LuqueAna Carolina Martini
Aug 28, 2010·International Journal of Peptides·Johannes D Veldhuis, Cyril Y Bowers
Nov 28, 2012·General and Comparative Endocrinology·Hiroyuki KaiyaMikiya Miyazato
May 9, 2012·Journal of Neuroendocrinology·S S StojilkovicC A Stratakis
Sep 1, 2012·General and Comparative Endocrinology·Caleb L Grey, John P Chang
Dec 25, 2012·General and Comparative Endocrinology·Caleb L Grey, John P Chang
Jun 7, 2016·Scientific Reports·William EverettAchala de Mel
Sep 11, 2019·Nutrients·Sara BecerrilGema Frühbeck
May 30, 2017·General and Comparative Endocrinology·Shayan AbtahiPaul J Currie

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