Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells.

The Journal of Clinical Investigation
Vishwa Deep DixitDennis D Taub

Abstract

Ghrelin, a recently described endogenous ligand for the growth hormone secretagogue receptor (GHS-R), is produced by stomach cells and is a potent circulating orexigen, controlling energy expenditure, adiposity, and growth hormone secretion. However, the functional role of ghrelin in regulation of immune responses remains undefined. Here we report that GHS-R and ghrelin are expressed in human T lymphocytes and monocytes, where ghrelin acts via GHS-R to specifically inhibit the expression of proinflammatory anorectic cytokines such as IL-1beta, IL-6, and TNF-alpha. Ghrelin led to a dose-dependent inhibition of leptin-induced cytokine expression, while leptin upregulated GHS-R expression on human T lymphocytes. These data suggest the existence of a reciprocal regulatory network by which ghrelin and leptin control immune cell activation and inflammation. Moreover, ghrelin also exerts potent anti-inflammatory effects and attenuates endotoxin-induced anorexia in a murine endotoxemia model. We believe this to be the first report demonstrating that ghrelin functions as a key signal, coupling the metabolic axis to the immune system, and supporting the potential use of ghrelin and GHS-R agonists in the management of disease-associated c...Continue Reading

References

Jan 1, 1988·Neuroscience and Biobehavioral Reviews·B L Hart
Sep 1, 1997·The Journal of Clinical Endocrinology and Metabolism·J E JanikW C Kopp
Feb 2, 1999·The EMBO Journal·F Sánchez-Madrid, M A del Pozo
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·G N LuheshiN J Rothwell
Feb 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·R FaggioniG Fantuzzi
Apr 25, 2000·Annual Review of Medicine·W B Ershler, E T Keller
Oct 18, 2000·Annals of Internal Medicine·D P Kotler
Nov 1, 2000·Nature·M TschöpM L Heiman
Feb 24, 2001·Nature·M NakazatoS Matsukura
Mar 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·P D LambertS J Wiegand
Apr 17, 2001·Current Opinion in Hematology·H BruunsgaardB K Pedersen
Aug 3, 2001·Nature Reviews. Neuroscience·A Inui
Jan 12, 2002·Nature Medicine·Ville WalleniusJohn-Olov Jansson
Feb 6, 2002·Nutrition·Alessandro LavianoFilippo Rossi-Fanelli
May 25, 2002·The New England Journal of Medicine·David E CummingsJonathan Q Purnell
Jun 7, 2002·The Journal of Clinical Endocrinology and Metabolism·Sharmilee GnanapavanMárta Korbonits
Oct 25, 2002·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·L PoppiN Parvizi
Dec 20, 2002·Nature·Jonathan Cohen
Jan 18, 2003·The Journal of Clinical Investigation·Veronica SannaGiuseppe Matarese
May 17, 2003·Neuroscience Letters·Nicole R BasaYvette Taché
Aug 20, 2003·The Journal of Clinical Investigation·Niels C RiedemannPeter A Ward
Oct 31, 2003·Molecular and Cellular Biology·Yuxiang SunRoy G Smith
Nov 5, 2003·Gastroenterology·Charles D R MurrayAnton V Emmanuel

❮ Previous
Next ❯

Citations

Dec 20, 2008·Diabetologia·K M AndralojcL Piemonti
Dec 27, 2011·Rheumatology International·Michal MagieraWlodzimierz Mazur
Jan 22, 2013·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Fatih Cem GülMetin Özgen
Jul 8, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Anja K BüscherPeter F Hoyer
Dec 12, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sujana S Gunta, Robert H Mak
Jun 21, 2011·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Martin Chasen, Ravi Bhargava
Aug 26, 2009·International Journal of Clinical Oncology·Masanori TakahashiGo Wakabayashi
Jan 4, 2013·Biogerontology·Moisés E BauerJos A Bosch
Mar 21, 2013·Cardiovascular Drugs and Therapy·Z W ShuX R Tan
Aug 5, 2008·Inflammation·Suleyman Serdar KocaAhmet Isik
Nov 2, 2013·Cellular Immunology·Douglas A Weigent
Jun 11, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Caroline M Pond
Mar 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Giuseppe MatareseSerafino Zappacosta
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Elena Gonzalez-ReyMario Delgado
Mar 11, 2006·The Journal of Biological Chemistry·Vishwa Deep DixitDennis D Taub
Feb 24, 2006·The Journal of Experimental Medicine·Elena Gonzalez-ReyMario Delgado
Jun 23, 2011·Journal of the National Cancer Institute·Gwen MurphyNeal D Freedman
Jun 18, 2009·Critical Care Medicine·Rongqian WuPing Wang
Aug 25, 2010·Current Opinion in Supportive and Palliative Care·Stephanie M Krasnow, Daniel L Marks
Jan 14, 2010·The Journal of Trauma·Rita O KwanGregory P Victorino
Jul 4, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Simona Perboni, Akio Inui
Dec 8, 2006·Annals of the Rheumatic Diseases·Elena Gonzalez-ReyMario Delgado
Oct 1, 2009·American Journal of Physiology. Endocrinology and Metabolism·Weizhen ZhangMichael W Mulholland
Aug 12, 2010·International Journal of Peptides·Leena PulkkinenMatti Uusitupa
Aug 20, 2010·International Journal of Peptides·Jen-Chieh Chuang, Jeffrey M Zigman
Aug 20, 2010·International Journal of Peptides·Wai W Cheung, Robert H Mak
Aug 17, 2011·International Journal of Peptides·Mark D Deboer
Sep 8, 2007·The Journal of Clinical Investigation·Vishwa Deep DixitDennis D Taub
Aug 26, 2011·Journal of Dental Research·K OhtaT Kawai
Sep 2, 2009·Blood·Hyunwon YangVishwa Deep Dixit
Jun 28, 2007·Reproductive Biology and Endocrinology : RB&E·Joanne L HarrisonDavid W Miller
Jun 1, 2010·Reproductive Biology and Endocrinology : RB&E·Margaret O'BrienTerry J Smith
Mar 21, 2013·Journal of Neuroinflammation·Amy L BeynonJeffrey S Davies
Aug 6, 2008·Journal of Leukocyte Biology·Laura PiccioAnne H Cross
Mar 20, 2008·The Journal of Clinical Endocrinology and Metabolism·Jianhua LiuMichael O Thorner
Jul 2, 2011·Molecular Endocrinology·Jen-Chieh ChuangJeffrey M Zigman
Apr 27, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Zygmunt WarzechaPeter C Konturek
Apr 10, 2013·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Dan YangQin Luo
Dec 16, 2004·PLoS Medicine·Patricia Prinz
May 3, 2007·PLoS Medicine·Ulrich E Schaible, Stefan H E Kaufmann

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Methods Mentioned

BETA
PCR
chip
acylation
ELISA

Software Mentioned

GeneAmp 7700 SDS
Spot Advanced
ABI prism

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