Ghrelin knockout mice display defective skeletal muscle regeneration and impaired satellite cell self-renewal

Endocrine
Elia AngelinoNicoletta Filigheddu

Abstract

Muscle regeneration depends on satellite cells (SCs), quiescent precursors that, in consequence of injury or pathological states such as muscular dystrophies, activate, proliferate, and differentiate to repair the damaged tissue. A subset of SCs undergoes self-renewal, thus preserving the SC pool and its regenerative potential. The peptides produced by the ghrelin gene, i.e., acylated ghrelin (AG), unacylated ghrelin (UnAG), and obestatin (Ob), affect skeletal muscle biology in several ways, not always with overlapping effects. In particular, UnAG and Ob promote SC self-renewal and myoblast differentiation, thus fostering muscle regeneration. To delineate the endogenous contribution of preproghrelin in muscle regeneration, we evaluated the repair process in Ghrl-/- mice upon CTX-induced injury. Although muscles from Ghrl-/- mice do not visibly differ from WT muscles in term of weight, structure, and SCs content, muscle regeneration after CTX-induced injury is impaired in Ghrl-/- mice, indicating that ghrelin-derived peptides actively participate in muscle repair. Remarkably, the lack of ghrelin gene impacts SC self-renewal during regeneration. Although we cannot discern the specific Ghrl-derived peptide responsible for such act...Continue Reading

References

Jan 5, 2007·Molecular Biology of the Cell·Nicoletta FilighedduAndrea Graziani
Feb 13, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ambikaipakan BalasubramaniamJ Howard James
Aug 9, 2011·Biochemical and Biophysical Research Communications·Keiichi KoshinakaMasamitsu Nakazato
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Jan 11, 2013·Physiological Reviews·Hang YinMichael A Rudnicki
Dec 7, 2013·Journal of the American Heart Association·Gabriele TogliattoMaria F Brizzi
Apr 15, 2014·Archivum Immunologiae Et Therapiae Experimentalis·Flavia Prodam, Nicoletta Filigheddu
Sep 27, 2014·European Journal of Pharmacology·Hironobu TsubouchiMasamitsu Nakazato
Mar 13, 2015·Molecular Therapy : the Journal of the American Society of Gene Therapy·Uxía Gurriarán-RodríguezJesús P Camiña
Jun 13, 2015·Nature Communications·Giulia RuoziMauro Giacca
Jul 3, 2015·Journal of Cachexia, Sarcopenia and Muscle·Ji-An ChenJose M Garcia
Aug 6, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gianluca Gortan CappellariRocco Barazzoni

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Citations

May 21, 2019·Expert Review of Endocrinology & Metabolism·Andrew GrannellCarel W le Roux
Jun 23, 2020·International Journal of Endocrinology·Yonas AkaluBirhanu Ayelign
Aug 25, 2021·Journal of Neuroendocrinology·Fiona Peris-SampedroSuzanne L Dickson
Nov 5, 2021·European Journal of Histochemistry : EJH·Giulia RonchiStefania Raimondo

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