Ghrelin potentiates growth hormone secretion driven by putative somatostatin withdrawal and resists inhibition by human corticotropin-releasing hormone

The Journal of Clinical Endocrinology and Metabolism
J D VeldhuisCyril Y Bowers

Abstract

Ghrelin is a 28-amino acid, Ser(3)-octanoylated peptide that stimulates GH secretion in vivo and in vitro. Beyond the capability of ghrelin to synergize with GHRH, little is known about multipeptide modulation of ghrelin's actions in humans. The objective of this study was to test the hypothesis that ghrelin can stimulate GH secretion in the absence or presence of somatostatin withdrawal (induced by l-arginine infusion) and stress-like drive by CRH. This was a randomized, double-blind, placebo-controlled, cross-over interventional study. This study was performed at an academic medical center. Nine healthy postmenopausal women not receiving sex hormones were studied. Subjects were given an iv infusion of saline and/or l-arginine or human CRH, followed by a bolus iv injection of ghrelin. The outcome measures were pulsatile GH secretion quantified by repetitive blood sampling, immunochemiluminometry, and deconvolution analysis. Consecutive saline/ghrelin infusion increased pulsatile GH secretion from 2.7 +/- 1.0 (saline/saline; mean +/- sem) to 20 +/- 5.0 microg/liter.3 h (P < 0.01). The magnitude of the effect of l-arginine/saline was comparable at 20 +/- 4.5 microg/liter.3 h (P < 0.01). In contrast, sequential l-arginine/ghrelin...Continue Reading

Citations

Jun 6, 2009·American Journal of Physiology. Endocrinology and Metabolism·Johannes D VeldhuisDana Erickson
Jul 10, 2008·The Journal of Clinical Endocrinology and Metabolism·Petra KokJohannes D Veldhuis
Feb 9, 2008·Molecular and Cellular Endocrinology·Raul M LuqueRhonda D Kineman
Aug 27, 2010·Journal of Fish Biology·J F LeatherlandS Barkataki
Dec 23, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Leon S FarhyJohannes D Veldhuis
Jun 15, 2007·The Journal of Clinical Endocrinology and Metabolism·Ali IranmaneshJohannes D Veldhuis
Mar 22, 2012·Endocrine Reviews·Manthos G GiannoulisPeter Sonksen
Feb 9, 2012·Experimental Biology and Medicine·Lloyd L Anderson, Colin G Scanes
Mar 27, 2020·Chemical Senses·Alastair J M Reith, Charles Spence
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

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