Ghrelin prevents 1-methyl-4-phenylpyridinium ion-induced cytotoxicity through antioxidation and NF-kappaB modulation in MES23.5 cells

Experimental Neurology
Li LiuJun-Xia Xie

Abstract

Ghrelin, a 28-amino acid peptide, is an endogenous ligand for the growth hormone secretagogue (GHS) receptor. Our previous data showed that ghrelin could inhibit apoptosis in Parkinson's disease (PD) models both in vitro and in vivo. There is now growing evidence that oxidative stress has a critical role in the etiology of PD. And ghrelin was reported to possess anti-inflammatory, antioxidant effects. Dose ghrelin protect dopaminergic neurons by its antioxidant effect? In the present study, 1-methyl-4-phenylpyridinium (MPP(+)) was used to evaluate the possible antioxidant effects of ghrelin on MPP(+)-induced neurotoxicity in MES23.5 cells and the underlying mechanisms. Our results showed that MPP(+) significantly increased malonaldehyde (MDA) level and Bax/Bcl2 ratio, reduced the level of Cu-Zn superoxide dismutase (SOD) and catalase (CAT). Ghrelin protected MES23.5 cells against MPP(+)-induced neurotoxicity by reversing these changes. Furthermore, ghrelin pretreatment significantly inhibited MPP(+)-induced nuclear factor-kappaB translocation. These results suggest that the protective effects of ghrelin on MPP(+)-induced cytotoxicity may be ascribed to its antioxidative properties, and the modulation of nuclear factor-kappaB.

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Citations

Mar 21, 2013·Journal of Neuroinflammation·Amy L BeynonJeffrey S Davies
Apr 15, 2014·Archivum Immunologiae Et Therapiae Experimentalis·Flavia Prodam, Nicoletta Filigheddu
Jan 17, 2014·Journal of Molecular Neuroscience : MN·Mohammad Moshahid KhanAsgar Zaheer
Sep 21, 2013·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Huamin XuJunxia Xie
Jan 27, 2016·Molecular Neurobiology·Limin ShiJunxia Xie
Jul 7, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Ning SongHong Jiang
Jun 2, 2011·Journal of Cellular Biochemistry·Jia-Hong ChenDah-Yuu Lu
Jan 1, 2021·Frontiers in Neuroscience·Niklas Reich, Christian Hölscher
Mar 26, 2021·Frontiers in Aging Neuroscience·Yanan ZhengLimin Shi
May 10, 2017·Journal of the Neurological Sciences·Kotaro YugeToyojiro Matsuishi
Jun 22, 2021·Human & Experimental Toxicology·R BademciO Erbaş
Dec 24, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity
Dec 10, 2021·Aging and Disease·Meiqiu LiuHong Jiang

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