Ghrelin response to protein and carbohydrate meals in relation to food intake and glycerol levels in obese subjects

Regulatory Peptides
Johannes ErdmannVolker Schusdziarra

Abstract

Obese subjects have lower basal and an attenuated decrease of postprandial plasma ghrelin following carbohydrate-rich meals, while the response to protein is unknown. Therefore, plasma ghrelin levels were examined after ingestion of satiating amounts of a protein- or carbohydrate-rich meal in relation to food and energy intake and hunger/satiety ratings in 30 obese subjects followed 240 min later by ad lib sandwiches. Food intake and hunger/satiety ratings were identical while energy intake was significantly greater after bread (861 +/- 62.7 vs. 441 +/- 50.4 kcal, p < 0.001). Second meal food and energy intake were not different. Ghrelin decreased after bread, but increased by 50 pg/ml (p < 0.001) after meat. The corresponding increase of insulin was 55 vs. 9 microU/ml (p < 0.001). Glycerol levels decreased significantly less after the protein meal compared to carbohydrates. After protein glycerol was significantly correlated to the rise of ghrelin but not insulin. These data demonstrate that, in obese subjects, protein has no different satiating effect than carbohydrate despite divergent ghrelin levels. Energy intake corresponds to energy density of the respective food items. Ghrelin response to both meals is qualitatively sim...Continue Reading

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Citations

Jan 17, 2008·The Journal of Clinical Endocrinology and Metabolism·Karen E Foster-SchubertDavid E Cummings
Jul 12, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Silvia Delgado-ArosIrene Busciglio
May 15, 2007·European Journal of Nutrition·Johannes ErdmannVolker Schusdziarra
Feb 4, 2012·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Anna Del PreteCarmelina Loguercio
May 2, 2008·Regulatory Peptides·Margriet S Westerterp-Plantenga
Jun 16, 2007·Regulatory Peptides·Johannes ErdmannVolker Schusdziarra
Jul 11, 2013·The Veterinary Journal·Karin E HemmannMarja R Raekallio
Jul 20, 2016·Annual Review of Nutrition·Alicia L CarreiroRichard D Mattes
Jul 11, 2020·European Journal of Nutrition·Kênia M B de CarvalhoVivian S S Gonçalves
May 13, 2008·The American Journal of Clinical Nutrition·Douglas Paddon-JonesMargriet Westerterp-Plantenga

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