Ghrelin secretion in preterm neonates progressively increases and is refractory to the inhibitory effect of food intake

The Journal of Clinical Endocrinology and Metabolism
S BelloneG Bona

Abstract

Ghrelin, a natural GH secretagogue, is mainly characterized by nonendocrine activities such as orexigenic effect and modulation of the endocrine and metabolic response to variations in energy balance. Ghrelin levels have been reported to be negatively associated with insulin secretion, enhanced in anorexia, and reduced in obesity. Ghrelin levels in newborns were shown to be similar to those found in children and adults without any gender-related difference. The aim of this study was to evaluate ghrelin variations in preterm newborns as a function of fasting and feeding. To this end, in 31 preterm neonates (13 males and 18 females) categorized as appropriate for gestational age, total ghrelin levels were measured in cord blood and then on the fourth day of life before and after meals. Ghrelin levels in cord blood [(median 25th-75th centile) 184; 122-275 pg/ml] were higher (P < 0.006) than levels measured in the mothers at delivery (167.0; 89-190 pg/ml). In newborns on the fourth day of life, ghrelin levels in fasting conditions (451; 348-649 pg/ml) were higher (P < 0.0004) than those in cord blood. The meal did not at all modify ghrelin levels (476; 302-775 pg/ml), which were unchanged, compared with those in fasting condition. ...Continue Reading

Citations

Nov 28, 2007·Journal of Pediatric Endocrinology & Metabolism : JPEM·Francesco SavinoRoberto Miniero
Dec 7, 2011·European Journal of Endocrinology·Hamilcikan SahinYildiz Perk
Mar 26, 2010·Pakistan Journal of Biological Sciences : PJBS·Safaa S ImamR Bahier
Jan 31, 2012·Early Human Development·Francesco SavinoLeandra Silvestro
Oct 31, 2014·American Journal of Medical Genetics. Part a·Frederick A KwehDaniel J Driscoll
Mar 8, 2014·The Journal of Clinical Endocrinology and Metabolism·Flavia ProdamGianni Bona
May 4, 2021·Journal of Neonatal-perinatal Medicine·T KoppB Weinberger
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

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