Ghrelin test for the assessment of GH status in successfully treated patients with acromegaly

European Journal of Endocrinology
S PekicV Popovic

Abstract

Posttreatment assessment of disease activity and definition of cure of acromegaly, using measurement of GH secretion, remains problematic. Furthermore, with our efforts to achieve tight biochemical control of the disease it is foreseeable that a proportion of patients may be rendered GH deficient, thus requiring testing for GH deficiency. The aim of our study was to evaluate residual GH secretion in cured patients with acromegaly. At baseline, circulating GH, IGF-I, IGFBP-3, leptin and lipid (cholesterol and tri-glycerides) levels were measured in 33 acromegalic patients nine years after treatment with surgery of whom 6 were additionally irradiated. Two tests were performed: the GH suppression test--oral glucose tolerance test (OGTT) and the GH provocation test--ghrelin test (1 microg/kg i.v. bolus) and the results were compared with 11 age- and sex-matched control subjects. According to the consensus criteria (normal IGF-I levels and post-OGTT GH nadir <1 microg/l), 21 treated acromegalic patients were cured, 6 had discordant IGF-I and GH nadir values during OGTT, while 6 had persistent acromegaly. After the GH provocative test with ghrelin (cut-off for severe GH deficiency is GH <3 microg/l), we detected 9 severely GH deficie...Continue Reading

Citations

Aug 25, 2012·Pituitary·Shingo FujioKazunori Arita
Mar 8, 2008·Endocrine Journal·Simoni A KatergariNikos K Nikolettos
Oct 4, 2011·European Journal of Endocrinology·Shozo YamadaYasuhiro Takeuchi
Aug 25, 2015·Endocrine Journal·Lara GiovanniniGiancarlo Balercia
Dec 2, 2014·Trends in Endocrinology and Metabolism : TEM·Gherardo MazziottiAndrea Giustina
Apr 7, 2010·Endocrinology·Manuel Gil-LozanoFederico Mallo
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

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