Giacomo Castelvetro's salads. Anti-HER2 oncogene nutraceuticals since the 17th century?

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Ramon ColomerJavier A Menendez

Abstract

We are accumulating evidence to suggest that 17(th) century Renaissance foodways -largely based on the old "Mediterranean dietary traditions"- may provide new nutraceutical management strategies against HER2-positive breast cancer disease in the 21st century. Epidemiological and experimental studies begin to support the notion that "The Sacred Law of Salads" (i.e., "raw vegetables... plenty of generous (olive) oil") -originally proposed in 1614 by Giacomo Castelvetro in its book The Fruit, Herbs & Vegetables of Italy- might be considered the first (unintended) example of customised diets for breast cancer prevention based on individual genetic make-up (i.e., nutraceuticals against human breast carcinomas bearing HER2 oncogene amplification/overexpression). First, the so-called salad vegetables dietary pattern (i.e., a high consumption of raw vegetables and olive oil) appears to exert a protective effect mostly confined to the HER2-positive breast cancer subtype, with no significant influence on the occurrence of HER2-negative breast cancers. Second, all the main olive oil constituents (i.e., the omega-9 monounsaturated fatty acid oleic acid and polyphenolic compounds such as the secoiridoid oleuropein or the lignan 1-[+]-acetox...Continue Reading

References

Oct 10, 1997·The American Journal of Clinical Nutrition·B Haber
Jul 7, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R W OwenH Bartsch
Sep 1, 2000·The American Journal of Clinical Nutrition·P Marckmann, A Astrup
Sep 1, 2000·The American Journal of Clinical Nutrition·F Visioli, C Galli
Nov 3, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J A MenendezR Colomer
Nov 4, 2004·Integrative Cancer Therapies·Carmia Borek
Nov 13, 2004·The Journal of Nutritional Biochemistry·Y I Kim
Feb 12, 2005·The Lancet Oncology·Roxanne Nelson
Mar 17, 2005·Frontiers in Bioscience : a Journal and Virtual Library·Yamini B TripathiBehram H Arjmandi
Sep 2, 2005·Nature·Gary K BeauchampPaul A S Breslin
Jan 7, 2006·Molecular Nutrition & Food Research·Vincenzo Fogliano, Raffaele Sacchi
Jan 13, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Javier A MenendezRuth Lupu
Mar 16, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Philippe BougnouxCharles Couet
Apr 25, 2006·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Ramón Colomer, Javier A Menéndez
May 4, 2006·Molecular Diagnosis & Therapy·Lynnette R Ferguson
May 10, 2006·Nature Clinical Practice. Oncology·Rita NahtaFrancisco J Esteva
May 18, 2006·Biotechnology and Applied Biochemistry·Edwin C M Mariman
Dec 1, 2006·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Javier A MenéndezRuth Lupu
Dec 16, 2006·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·E EscrichL Grau
Apr 25, 2007·International Journal of Cancer. Journal International Du Cancer·Milena SantFranco Berrino

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Citations

Jun 4, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Melissa Marie AlegreKim Leslie O'Neill

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