PMID: 3773143Nov 7, 1986Paper

Gianotti-Crosti syndrome associated with infections other than hepatitis B

JAMA : the Journal of the American Medical Association
Z K DraelosW D James

Abstract

Although the Gianotti-Crosti syndrome (GCS) is regularly associated with hepatitis B infection elsewhere, in North America that association is rarely made. Accordingly, we studied nine children with acral, symmetrical eruptions typical of GCS for evidence of other infections. All were negative for hepatitis B surface antigen. Viral cultures were done in nine patients, and viruses isolated in two. One patient with a respiratory prodrome had respiratory syncytial virus (RSV) isolated, and a second patient studied simultaneously showed serological evidence of RSV infection. A third patient with both respiratory tract and gastrointestinal tract symptoms yielded a polio-vaccine enterovirus. Two patients with fever and pharyngitis had group A beta-hemolytic streptococci isolated from the throat. Skin biopsies were done in three cases, and findings were consistent with GCS. Electron microscopy of two lesional biopsy specimens failed to demonstrate viral particles. Epstein-Barr virus serological findings were negative in six cases and showed evidence of past infection in three cases. This study strengthens the observation that hepatitis B is not the causative agent of GCS in this country and suggests that multiple infectious agents may...Continue Reading

Citations

Dec 3, 2014·Clinics in Dermatology·Oktay Avci, Ilgen Ertam
Aug 16, 2000·Current Opinion in Pediatrics·J S Nelson, M S Stone
Apr 19, 2000·The American Journal of Dermatopathology·C M StefanatoJ Bhawan
Aug 9, 2012·Asia Pacific Allergy·Genevieve Villablanca LlanoraHugo Ps van Bever
Jul 18, 2002·Dermatologic Clinics·Allyson M JonesStephen K Tyring
Mar 1, 1991·Current Problems in Pediatrics·N S Prose, S D Resnick
Mar 1, 1990·Clinical Pediatrics·H C WeinermanK L Cates
Dec 13, 2016·International Journal of Dermatology·Vijay Zawar, Antonio Chuh
Jun 12, 1999·Pediatrics International : Official Journal of the Japan Pediatric Society·S MaedaI Mitsuto

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