Giant Basal Cell Carcinoma: A 12-Year Follow-up Case Report

The American Journal of Dermatopathology
Fabiola Jiménez-HernándezJosé A Ramos-Garibay

Abstract

Giant basal cell carcinomas (GBCCs) are a strange and aggressive variety of basal cell carcinomas (BCCs); they are characterized by deep tissue invasion, rapid growth, high risk of metastasis, and a poor prognosis. GBCCs represent 0.4%-1% of all BCCs. The pathogenesis of GBCC is sometimes linked to a spontaneous mutation in the PTCH gene, mapped to the q22.33 locus of chromosome 9. The key factor in the development of GBCC, in at least 30% of the cases, is the delay in seeking medical attention (7.5 ± 3.1 years). This is associated to a poor socioeconomic level, deficient hygiene, mental illness, advanced age, and the fact that BCCs are painless lesions. The authors present a Mexican female with a 2-year ulcer diagnosed as a GBCC in the year 2000, its initial therapeutic approach, and her follow-up during the next 12 years.

References

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Citations

May 16, 2018·Rare Tumors·Mariana Orduz RobledoArjen F Nikkels
Sep 20, 2019·Clinical Case Reports·Luiza Fiszon-CerqueiraMaria Kátia Gomes

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