Giant cell aortitis and Noonan syndrome

Congenital Heart Disease
Shaji MenonDavid Driscoll

Abstract

An 18-year-old girl with Noonan syndrome was diagnosed with progressive aneurysmal dilatation of the ascending aorta. Histopathological examination revealed giant cell aortitis. Connective tissue abnormalities leading to aortic root dilatation and the sinuses of Valsalva aneurysm have been reported in Noonan syndrome. This report is the first description of giant cell aortitis in Noonan syndrome and may provide a link between aortic aneurysm, and giant cell granuloma of bone in Noonan syndrome.

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Citations

Nov 14, 2013·The American Journal of Cardiology·James W CornwallBruce D Gelb
Oct 13, 2016·IEEE Journal of Translational Engineering in Health and Medicine·Michael A RothfussErvin Sejdic
Jul 20, 2018·Current Opinion in Pediatrics·Mary Ella Pierpont, Maria Cristina Digilio
Nov 27, 2020·American Journal of Medical Genetics. Part a·Elizabeth I PierpontWilliam B Dobyns

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