Giant cell arteritis

Clinical & Experimental Ophthalmology
Stuart C CarrollHelen V Danesh-Meyer

Abstract

Giant cell arteritis (GCA) is an immune-mediated vasculitis, affecting medium- to large-sized arteries, in individuals over the age of 50 years. Visual loss is a frequent complication of GCA, and once it occurs it tends to be both permanent and profound. Although major advances have been made in recent years in genetics, molecular biology and the description of the vessel wall morphology, the aetiology and pathogenesis of GCA are still incompletely understood. Over the years there has been much debate over whether polymyalgia rheumatica and GCA are separate or linked entities. Recent investigations support that polymyalgia rheumatica and GCA are two different expressions of the same underlying vasculitic disorder. A single cause or aetiological agent has not as yet been identified. Except for the histopathology of the arterial wall, there are no laboratory findings specific for GCA, and no particular signs or symptoms specific for the diagnosis. GCA typically causes vasculitis of the extracranial branches of the aorta and spares intracranial vessels. Transmural inflammation of the arteries induces luminal occlusion through intimal hyperplasia. Clinical symptoms reflect end-organ ischaemia. Branches of the external and internal ...Continue Reading

References

Jan 1, 1978·Annual Review of Medicine·R E EttlingerL E Ward
Jun 1, 1979·Annals of the Rheumatic Diseases·A L BergströmJ Kutti
Apr 1, 1979·Scottish Medical Journal·F JonassonR A Elton
Feb 1, 1978·Annals of Internal Medicine·K A HustonL R Elveback
Dec 1, 1976·Archives of Ophthalmology·D M AlbertJ L Keltner
Jan 1, 1976·Survey of Ophthalmology·J F Cullen, J A Coleiro
Jan 1, 1992·European Journal of Clinical Pharmacology·P J HayballP J Roberts-Thomson
Nov 1, 1991·The British Journal of Ophthalmology·G P BrittainJ M Gibson
Dec 1, 1991·Baillière's Clinical Rheumatology·L A Healey
Dec 1, 1991·Baillière's Clinical Rheumatology·S S Hayreh
Dec 1, 1991·Baillière's Clinical Rheumatology·V Kyle
Apr 1, 1990·Journal of Internal Medicine·E Nordborg, B A Bengtsson
Mar 1, 1989·Cleveland Clinic Journal of Medicine·S D Deodhar
Feb 1, 1986·Annals of the Rheumatic Diseases·M De Silva, B L Hazleman
Jul 1, 1987·Archives of Ophthalmology·D M Jacobson, T L Slamovits
Apr 1, 1986·Ophthalmology·P J McDonnellW R Green
Jan 1, 1970·American Journal of Ophthalmology·P HenkindJ Pearson
Oct 1, 1972·The British Journal of Ophthalmology·S S Hayreh, J A Baines
Oct 1, 1972·The British Journal of Ophthalmology·S S Hayreh, J A Baines
Dec 1, 1974·The British Journal of Ophthalmology·E M EaglingS J Miller
Dec 1, 1972·Annals of Internal Medicine·P FauchaldB Oystese
Jan 22, 1983·British Medical Journal·A MillerD Robinson
Nov 1, 1984·Mayo Clinic Proceedings·S Hall, G G Hunder
Dec 15, 1984·American Journal of Ophthalmology·R SpolaoreJ de Margerie
Jun 1, 1984·Annals of the Rheumatic Diseases·M C Allison, P J Gallagher
Apr 1, 1983·Annals of the Rheumatic Diseases·M E Ellis, S Ralston
Jul 9, 1981·The New England Journal of Medicine·J BarrierJ Grolleau
Nov 1, 1982·Annals of Internal Medicine·T Y ChuangL T Kurland
Jul 1, 1980·American Heart Journal·K A Huston, G G Hunder
Nov 5, 1982·JAMA : the Journal of the American Medical Association·J BarrierJ Y Grolleau
Oct 1, 1982·Ophthalmology·J L Keltner
Nov 1, 1980·Ophthalmology·J Eshaghian, J A Goeken

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Citations

Apr 16, 2010·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·A BrüggemannM Müller
Mar 12, 2009·Clinical Rheumatology·M BrodmannE Pilger
Jun 23, 2011·Therapeutic Advances in Neurological Disorders·Elke VossMartin Stangel
Sep 12, 2014·Journal of Indian Society of Periodontology·Sanjay VasudevanRadhika Challa
Apr 29, 2014·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Bethany DurlingDavid Jordan
Jan 22, 2013·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Noboru NomaYoshiki Imamura
May 28, 2013·Drug Discovery Today·Erasmia BroussalisMonika Killer
Sep 8, 2010·Neurologic Clinics·Byron Roderick Spencer, Kathleen B Digre
Oct 17, 2009·Survey of Ophthalmology·Efstratios MendrinosConstantin J Pournaras
May 27, 2008·Survey of Ophthalmology·Edlira BendoRod Foroozan
Aug 24, 2013·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Alicia MattiaRobert Hammond
Aug 9, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Elisabeth De SmitAlex W Hewitt
Dec 1, 2007·International Ophthalmology Clinics·Stacy L Pineles, Anthony C Arnold
Oct 22, 2008·Acta Ophthalmologica·Aki Kawasaki, Valerie Purvin
May 27, 2010·Clinical and Experimental Dermatology·S A Ghaffar, P M Todd
Sep 3, 2010·Current Opinion in Ophthalmology·Nilufer Kale, Eric Eggenberger
Apr 22, 2006·Clinical & Experimental Ophthalmology·Peter J Savino
Jul 9, 2009·International Ophthalmology Clinics·Jonathan G Haymore, Luis J Mejico
Jun 27, 2020·Indian Journal of Ophthalmology·Somasheila I MurthyAnuj Soni
May 14, 2009·Seminars in Ophthalmology·Ellen Browne Mitchell, Dean M Cestari
Mar 19, 2021·Vascular Medicine·Gerardo Ruiz-AresExuperio Díez-Tejedor

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