Giant cell bone lesions in the craniofacial region: a diagnostic and therapeutic challenge

International Forum of Allergy & Rhinology
Bruno Barros Pinto BorgesRichard Louis Voegels

Abstract

Giant cell tumors of bone (GCTs) are common in the long bones, but rare in the craniofacial region, with only 1% of cases occurring in the latter. Clinical, radiological, and anatomical diagnosis of this locally aggressive disease, which occurs in response to trauma or neoplastic transformation, poses a major challenge in clinical practice. The present study describes a series of 4 cases and highlights the main features of the differential diagnosis and treatment of these lesions: GCT, giant cell reparative granuloma (GCRG), and the brown tumor of hyperparathyroidism. GCT presents as a benign neoplasm, most typically affecting the knees, and rarely in the temporal and sphenoid bones. It is radiologically indistinguishable from GCRG due to its lytic, poorly defined appearance. The distinction can only be made microscopically, as the presence of multinucleated giant cells scattered throughout the stroma and the absence of a history of trauma favor a diagnosis of GCT. The brown tumor of hyperparathyroidism occurs with rapid, localized osteoclast activity secondary to the effects of increased parathyroid hormone (PTH) levels; parathyroid examination is indispensable. The diagnosis and treatment of these lesions poses a major challe...Continue Reading

References

Aug 1, 1983·Journal of Neurosurgery·J T WolfeD C Dahlin
Jun 18, 2002·Neurologia Medico-chirurgica·Toru MatsuiHiroo Tabe
Jun 27, 2006·American Journal of Otolaryngology·Katherine TriantafillidouFotis Iordanidis
Jun 29, 2006·Acta Oto-laryngologica·Gino MarioniAlberto Staffieri
Dec 13, 2006·Arquivos brasileiros de endocrinologia e metabologia·Christianne T S LealMaria Lucia F Farias
Jan 14, 2009·Archives of Neurology·Maria Margarita Company, Rafael Ramos
Aug 1, 2009·Head and Neck Pathology·Elizabeth BilodeauBobby Collins
Oct 16, 2009·Journal of Medical Case Reports·Efklidis ProimosChariton E Papadakis
Mar 12, 2010·International Journal of Pediatric Otorhinolaryngology·Erkan OrhanBülent Erdoğan

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Citations

Jun 13, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Michael P WhyteNicholas J Shaw

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