Giant cell osteosarcoma in the calvarium of a cat

Veterinary Pathology
A NegrinMassimo Castagnaro

Abstract

Feline primary osteosarcomas involving the skull are extremely rare. When they occur, orbit, mandible, and maxilla are the most common sites. Microscopically, scattered multinucleated giant cells (MGCs) are not an uncommon occurrence in osteosarcoma (OSC), but they are generally in low number. Only in a rare variant, the giant cell-rich OSC, are MGCs the prevalent cell type. Although osteoclast and osteoblast origin have been postulated in human and veterinary literature, the origin of MGCs in osteosarcomas is poorly understood. This report describes a giant cell-rich OSC in the calvarium of a 13-year-old spayed female shorthair cat. The animal exhibited a range of neurologic signs, including left circling, compulsive gait, lack of proprioception, and bilateral absence of menace reaction, with indication of left forebrain involvement. Gross lesions were characterized by a multilobate, spherical mass located in the left calvarium, compressing the left forebrain. Histologically, the tumor was characterized by scattered nests of MGCs separated by small bundles of pleomorphic, fusate to polygonal cells. Between spindle cells, osteoid was very sparse and arranged in thin strands. Immunohistochemical stains for vimentin were positive...Continue Reading

References

Oct 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·F P ReinholtG Andersson
Nov 1, 1983·Veterinary Pathology·P J Quigley, A H Leedale
Jul 1, 1995·Histopathology·R SciotV Desmet
May 1, 1997·Zentralblatt für Veterinärmedizin. Reihe A·M Jösten, R Rudolph
Dec 6, 2000·Journal of the American Animal Hospital Association·E HeldmannC Wagner-Mann

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Citations

Feb 8, 2011·Clinics in Laboratory Medicine·Leslie C Sharkey, Maxey L Wellman
Apr 5, 2008·Journal of Feline Medicine and Surgery·Shih-Chieh ChangFeng-Pang Cheng
Feb 14, 2012·Toxicologic Pathology·Enrico RadaelliEugenio Scanziani
Jul 28, 2017·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Alonso Reyes-MatuteLiliana-Aurora Ramos-Garduño
May 28, 2019·Veterinary Sciences·Kelly M MakielskiJaime F Modiano

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Methods Mentioned

BETA
transmission electron microscopy

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