PMID: 8597862Sep 1, 1995Paper

Giant cell tumor in the skull of a 9-year-old child: immunohistochemistry to confirm a diagnosis rare for age and site

Pediatric Pathology & Laboratory Medicine : Journal of the Society for Pediatric Pathology, Affiliated with the International Paediatric Pathology Association
A CurilovicT Stallmach

Abstract

Giant cell tumor of the bone is usually located within the epiphysis of a long bone, the majority of the lesions occurring in the third and fourth decades of life. We report an unusual case of giant cell tumor (GCT) arising in the parietal skull bone of a 9-year-old girl. The tumor exhibited histologic findings typical for GCT, with conspicuous intravascular giant cells. Based on microscopic features, not only conditions like aneurysmal bone cyst or bone changes associated with hyperparathyroidism but also tumors such as chondroblastoma or osteosarcoma had to be considered. Immunohistochemistry revealed strong reactivity of the tumor giant cells and normal bone osteoclasts with CD68 but not Mac-387; tumor stromal cells were uniformly negative for both. The stromal cells exhibited two immunohistochemically distinct phenotypes. One, involving 50-80% of the tumor cells, exhibited negative lysozyme staining with positivity of proliferating cell nuclear antigen (PCNA) in about 30% of the nuclei. The other showed reactivity with lysozyme but negative PCNA staining. Immunohistochemistry thus helped to distinguish chondroblastoma and osteosarcoma, in which lysozyme positivity would reside in macrophages but not within stromal cells. In...Continue Reading

References

Feb 9, 1979·Virchows Archiv. A, Pathological Anatomy and Histology·T AparisiJ L Ericsson
Aug 1, 1979·British Journal of Cancer·K KasaharaA Kasahara
Sep 1, 1992·Cancer·F BertoniM J Ebersold
Jul 11, 1992·Radiology·M J KransdorfR P Moser
Feb 1, 1987·The Journal of Clinical Investigation·S R GoldringA K Bhan
Aug 1, 1988·Oral Surgery, Oral Medicine, and Oral Pathology·P L AuclairG L Ellis
Apr 1, 1993·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·R ErlemannG Edel
Jan 1, 1993·Skeletal Radiology·H E Schütte, W K Taconis

❮ Previous
Next ❯

Citations

Jul 25, 2003·Pediatric Neurology·Hilda Bibas-BonetJudith Nieman
Sep 7, 2012·Case Reports in Otolaryngology·Takashi IizukaKatsuhisa Ikeda
Jun 24, 2014·Case Reports in Otolaryngology·Jumpei NotaTadahiko Saiki
Jul 25, 2007·Journal of Neurosurgery·James B ElderJ Gordon McComb
Dec 11, 2002·Neurologia Medico-chirurgica·Junichi YoshimuraHitoshi Takahashi
Nov 30, 2011·Neurologia Medico-chirurgica·Yuuta KamoshimaKiyohiro Houkin
Jun 20, 2020·Journal of the American Podiatric Medical Association·Amber HaseebPailoor Jayalakshmi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Cell Wall Structure (ASM)

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Related Papers

Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
A GermanòE Cardia
Klinische Monatsblätter für Augenheilkunde
M M Moschos, Y Guex-Crosier
© 2021 Meta ULC. All rights reserved