Giant cell tumor of bonelike lesion in a Trp53 mutant mouse

Toxicologic Pathology
Enrico RadaelliEugenio Scanziani

Abstract

Giant cell tumor of bone (GCTB) is a common primary neoplasm of bone characterized by distinctive clinicopathological features. GCTB is exceedingly rare in nonhuman species, and it has been sporadically reported in cats, dogs, rats, and birds. This report describes a primary murine bone tumor that shares striking clinicopathological similarities with human GCTB. The neoplasm occurred in a 71-week-old C57BL/6 mouse heterozygous for the specific Trp53 R172H point mutation. Grossly, the tumor presented as a mono-ostotic nodular mass arising from the distal metaphysis of the right femur. Microscopically, the affected bone was effaced by an osteolytic neoplasm with focal infiltrations into the surrounding tissues. Similarly to what was reported for human GCTB, the murine neoplasm consisted of 3 main cell populations: (1) bundles of pleomorphic spindle-shaped mononuclear cells displaying an indefinite mesenchymal histogenesis with immunohistochemical expression of vimentin and smooth muscle actin, (2) scattered multinucleated giant cells exhibiting osteoclast differentiation with prominent tartrate-resistant acid phosphatase activity and immunoreactivity for monocyte/macrophage markers including CD45 and lysozyme, and (3) scattered r...Continue Reading

References

Nov 1, 1985·Journal of the National Cancer Institute·J T WilsonB Ryffel
Jul 1, 1985·Pathology, Research and Practice·V BouropoulouZ Manika
May 1, 1974·Laboratory Animals·R T Charles, V S Turusov
Jul 1, 1995·The Journal of Small Animal Practice·B A Walsh, W H Rhodes
Dec 1, 1994·The Journal of Bone and Joint Surgery. American Volume·R J O'DonnellH J Mankin
Jul 5, 1996·Journal of the Autonomic Nervous System·Y SatoH Suzuki
Nov 15, 1997·Pathology International·K WatanabeT Suzuki
Dec 24, 1998·Toxicologic Pathology·T ImaiF Sagami
Oct 29, 2000·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·N MiyamotoY Ito
Aug 15, 2001·Journal of Cancer Research and Clinical Oncology·M WüllingE Kaiser
Feb 28, 2002·American Journal of Clinical Pathology·Sophie RouxXavier Mariette
Oct 2, 2002·Current Oncology Reports·Alan W Yasko
May 7, 2003·Cancer·Franco BertoniEric L Staals
Jul 17, 2003·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Dror RobinsonZvi Nevo
Nov 11, 2003·Human Pathology·Manuela WüllingEdelgard Kaiser
Dec 21, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ted S LiaoFrancis Young-In Lee
Jun 10, 2005·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·M C FerrerasJ F García-Marín
Feb 8, 2006·American Journal of Clinical Oncology·William M MendenhallNancy P Mendenhall
Mar 16, 2006·Veterinary Pathology·A NegrinM Castagnaro
Oct 3, 2006·International Orthopaedics·Mathias Werner
Apr 28, 2007·Avian Diseases·Olga AmannNico J Schoemaker
May 3, 2008·The Journal of Bone and Joint Surgery. American Volume·UNKNOWN Arbeitsgemeinschaft KnochentumorenPer-Ulf Tunn
Jun 11, 2008·Clinical Orthopaedics and Related Research·Manuela SalernoNicola Baldini
May 16, 2009·Current Opinion in Oncology·David M Thomas, Keith M Skubitz
Dec 17, 2009·Virchows Archiv : an International Journal of Pathology·M AlberghiniN A Athanasou
Feb 24, 2011·Veterinary Pathology·A M KavirayaniO Foreman
Jul 12, 2011·Cancer Cell·Javier E GirardiniGiannino Del Sal

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Citations

Oct 16, 2012·Bone·Robert W Cowan, Gurmit Singh

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Methods Mentioned

BETA
transgenic
SMA

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