Giant cell tumor of the extrahepatic biliary tree: a clinicopathologic study of 4 cases and comparison with anaplastic spindle and giant cell carcinoma with osteoclast-like giant cells

The American Journal of Surgical Pathology
J Albores-SaavedraZ D Goodman

Abstract

We report four previously undescribed primary giant cell tumors of the extrahepatic biliary tree and morphologically compare them with 10 anaplastic spindle and giant cell carcinomas with osteoclast-like giant cells of the gallbladder. Two giant cell tumors were located in the distal common bile duct; one in the cystic duct and one in the gallbladder. The 3 patients with bile duct tumors were male, and the only patient with a gallbladder tumor was a female. The age of the patients ranged from 45 to 60 years with an average of 55 years. The patients with bile duct tumors presented with biliary obstruction, and the patient with a gallbladder tumor presented with symptoms of cholelithiasis and a gallbladder mass. Histologically, the tumors were similar to giant cell tumors of bone. They consisted of a mixture of mononuclear and multinucleated osteoclast-like giant cells. The mononuclear cells showed no atypical features, and their nuclei were similar to those of the multinucleated giant cells. CD163 immunoreactivity was restricted to the mononuclear cells, whereas CD68 and HAM 56 labeled only the multinucleated osteoclast-like giant cells. The mononuclear cells were EMA-positive but did not express cytokeratins. Follow-up showed t...Continue Reading

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Citations

Nov 30, 2013·International Journal of Colorectal Disease·Theodoros KolokotronisFrank Grünhage
Apr 7, 2007·Current Opinion in Gastroenterology·Jay H Lefkowitch
Jan 29, 2008·The American Journal of Surgical Pathology·Deepti Dhall, David S Klimstra
Jul 6, 2007·Pathology International·Sohei YamamotoOsamu Matsubara
Apr 21, 2010·Pathology International·Hiroe ItamiToshiko Sakuma
Jan 21, 2017·Pathology International·Aurélie BeaufrèreDominique Cazals-Hatem
Jun 25, 2010·Advances in Anatomic Pathology·Kemal Behzatoğlu
Apr 9, 2015·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Jennifer A BennettEsther Oliva
Nov 12, 2014·World Journal of Gastroenterology : WJG·Dan-Dan WangDe-Hong Lu
Jan 15, 2018·Acta Cytologica·José A Jiménez-HeffernanJavier Fraga
Jan 21, 2021·Pathology International·Daisuke MoriKenji Kitahara
Jul 15, 2021·Pathology Oncology Research : POR·Kemal Behzatoglu

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