Giant congenital melanocytic nevi and malignant transformation: a case for early radical intervention

Pediatric Surgery International
Christopher R MaguireRoy M Kimble

Abstract

The purpose of this paper is to highlight the risk of early malignant transformation in infants with giant congenital melanocytic nevi (GN) and demonstrate the potential for earlier intervention with aggressive surgery. We describe the case of a child born with a GN who developed a metastatic melanoma early in life, despite early commencement of resection of the nevus. This is contrasted against a second case of a child in which a more radical management was conducted. Despite early commencement of serial resection of the GN, the first child in this series died of metastatic melanoma prior to complete excision of the nevus. With the second child, radical excision combined with the use of Integra™ and negative pressure wound therapy allowed total removal of the GN within the first 6 months of life.

References

Aug 1, 1979·Journal of the American Academy of Dermatology·A W KopfP Hennessey
Jun 1, 1992·The Journal of Pediatrics·R Ruiz-MaldonadoC Durán
Jun 24, 2006·The British Journal of Dermatology·S KrengelT Schäfer
Oct 11, 2007·International Wound Journal·Judith E HunterPaul E Banwell
Jul 18, 2012·Dermatologic Clinics·Sven Krengel, Ashfaq A Marghoob
Jul 26, 2014·Pediatric Surgery International·Craig A McBrideRoy M Kimble

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Citations

Feb 21, 2019·Diagnostic Pathology·Tatiana S BelyshevaMamed D Aliev
Jun 22, 2020·Annales de dermatologie et de vénéréologie·M Masson RegnaultS Fraitag

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