Giant keratoacanthoma: case report and review of the English literature

The American Journal of Dermatopathology
Paul N BognerNathalie C Zeitouni

Abstract

The giant keratoacanthoma (KA) is a rare variant of KA with a maximum size exceeding 2-3 cm. Like other forms of KA, it has a tendency to spontaneously regress but can cause significant anatomic damage. A 69-year-old male presented to our hospital with a giant KA of the nose that showed complete pathological regression by the time of surgery. Pathology showed dermal scar with keratin granulomas extending through the nasal wall to the respiratory mucosa. A total of 57 similar cases from the English literature were reviewed for comparison. Few provide similar details of histological regression. Literature cases occurred predominately in males (74.1%) with a mean age of 59 years. Head tumors were most common (70.7%) and most were treated by surgery (34.5%) or a combination of surgery and radiotherapy (24.1%). Other treatment modalities reported include methotrexate, 5-fluorouracil, and interferon.

References

Dec 1, 1979·Journal of Surgical Oncology·R A Schwartz
Jan 1, 1979·Oncology·R A Schwartz
Aug 1, 1979·Annals of Plastic Surgery·K PickrellH Neale
Jun 1, 1978·The Journal of Dermatologic Surgery and Oncology·A W Kopf, R S Bart
Jun 1, 1975·The Journal of Dermatologic Surgery·R S BartS L Gumport
Sep 1, 1990·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·B A EdelmanR Auerbach
Feb 1, 1985·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·F E Lucente
Mar 1, 1986·The Journal of Dermatologic Surgery and Oncology·W A PaganiD Lorusso
Apr 1, 1966·The Journal of Pathology and Bacteriology·A J Webb, F N Ghadially
Nov 1, 1981·The Journal of Dermatologic Surgery and Oncology·S WolinskyE W Herman
Oct 1, 1980·Journal of Cutaneous Pathology·W H Kern, M K McCray
Aug 1, 1993·Journal of the American Academy of Dermatology·J J GrobJ J Bonerandi
Sep 1, 1993·Archives of Dermatology·H Goldschmidt, W K Sherwin
Feb 1, 1996·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Jan G A M de VisscherI van der Waal
Dec 3, 1999·The British Journal of Dermatology·S Radakovic-FijanA Tanew
Mar 25, 2000·Auris, Nasus, Larynx·M MoriyamaG Mogi
May 4, 2000·Acta Ophthalmologica Scandinavica·G A AlyahyaJ U Prause
Jul 15, 2000·Dermatology : International Journal for Clinical and Investigative Dermatology·K SpiethR Kaufmann
Jan 5, 2002·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Jan G A M de VisscherFeike Willemse
Mar 6, 2003·Plastic and Reconstructive Surgery·Masataka SaitoHiroshi Shimizu
Mar 6, 2003·Plastic and Reconstructive Surgery·Eksal KargiBerfu Babuccu
Jun 26, 2003·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·D E KyrmizakisE Helidonis
Aug 1, 1958·A.M.A. Archives of Dermatology·A KALLOS
Apr 1, 1962·Archives of Dermatology·F F HELLIER, N R ROWELL
Nov 18, 2003·The Australasian Journal of Dermatology·Leah M GieseckeShyamala C Huilgol
Aug 17, 2004·British Journal of Plastic Surgery·Richard W Griffiths
Dec 21, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Jens J ThielePeter Elsner
Mar 25, 2008·The American Journal of Dermatopathology·Steven KossardCarolyn Choy
May 14, 2011·Clinical and Experimental Dermatology·F BrowneG Stables

Citations

Nov 30, 2014·Practical Radiation Oncology·Daniel P LindsayJ Frank Wilson
Sep 28, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·C BaykalA Polat Ekinci
Dec 10, 2014·Journal of Cutaneous Pathology·Steven Kossard
Jun 7, 2017·Case Reports in Pathology·Jason E CohnKenneth Briskin

Related Concepts

Keratoacanthoma
External Nose Structure
Dermatologic Disorders
Keratin-13
Fluorouracil
Granuloma
Hospitals
Interferons
Literature
Methotrexate

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