Giant keratoacanthoma in an immunocompetent patient with detection of HPV 11

Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete
M NiebuhrT Werfel

Abstract

A 47-year-old immunocompetent man presented with a nodule on the right side of the upper lip that appeared suddenly and grew rapidly. Histological examination was consistent with the diagnosis of keratoacanthoma which is often associated with immunosuppression. Low-risk HPV type 11 was detected in the PCR analysis. While formerly one often waited for spontaneous regression of keratoacanthomas, today one routinely treats them as a well-differentiated squamous cell carcinoma. Complete surgical excision was not possible in our patient because of the size of the tumor. Radiation with a cumulative dose of 30 Gray (15 sessions of 2 Gray) led to complete remission. In addition to ultraviolet exposure, trauma, genetic factors and chemical carcinogens, HPV should be considered as a possible cofactor in the etiology of keratoacanthoma.

References

Mar 1, 1996·Archives of Dermatological Research·S LuS Syrjänen
May 15, 1999·Dermatology : International Journal for Clinical and Investigative Dermatology·E StockflethT Meyer
Mar 25, 2000·Auris, Nasus, Larynx·M MoriyamaG Mogi
Jul 16, 2003·Journal of Cutaneous Pathology·Ola ForslundOle Petter F Clausen
Feb 12, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Robert A Schwartz
Mar 20, 2004·Journal of Cataract and Refractive Surgery·Vijay K DadaMayank S Pangtey

Citations

Jul 18, 2014·Dermatologic Therapy·N BruscinoG M Palleschi
Feb 23, 2019·Dermatology and Therapy·Hélène MascittiNicole Basset-Seguin

Related Concepts

Biopsy
Combined Modality Therapy
Differential Diagnosis
Immunocompetence
Keratoacanthoma
Lip Diseases
Skin
Nested Polymerase Chain Reaction
Radiotherapy, Adjuvant
Papillomavirus Infections

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.