Giant left ventricular rhabdomyoma treated successfully with everolimus: case report and review of literature

Cardiology in the Young
Alfonso Martínez-GarcíaJorge A Cardona-Pérez

Abstract

IntroductionIntracardiac rhabdomyomas can cause severe ventricular dysfunction and outflow tract obstruction.Case reportA term newborn infant with antenatal diagnosis of giant left ventricle rhabdomyoma presented with cardiac failure and duct-dependent systemic circulation after birth. She was treated successfully with everolimus, showing decrease in tumour size and improvement in left ventricular ejection fraction.DiscussionTumour regression rate was 0.32 cm2/day and improved to 0.80 cm2/day with the use of everolimus. Herein we report a newborn with inoperable giant left ventricular cardiac rhabdomyoma and significant regression of the tumour. To our knowledge, this is the largest left ventricular rhabdomyoma reported. A review of the literature was undertaken for comparison. Everolimus has proven to be efficacious in size reduction of cardiac rhabdomyomas in cases when surgical resection is not possible.

References

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Citations

Mar 22, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Candice Torres de Melo Bezerra CavalcanteKlebia Magalhães Castello Branco
Jul 11, 2019·Prenatal Diagnosis·Luisa F Mariscal-MendizábalMónica Aguinaga-Ríos
Nov 20, 2019·Prenatal Diagnosis·Ilina D PluymDeborah Krakow
Feb 16, 2021·Clinics in Perinatology·Tooba RashidMichael D Deel
Feb 17, 2021·American Journal of Medical Genetics. Part a·María P Silva-SánchezCarlos E Prada
Jun 3, 2021·International Journal of Environmental Research and Public Health·Monika SugalskaBożena Werner
Nov 15, 2021·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Joseph J MaleszewskiFabio Tavora

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