Abstract
Nonmelanoma skin cancers (NMSCs) are the most common type of skin tumor, representing about one-third of all malignancies diagnosed worldwide each year. Cutaneous squamous cell carcinoma (cSCC) is the second most common form of NMSCs and the risk of cSCC invasiveness should be assessed on the basis of tumor size, anatomical location, and histological subtype. Although most cSCCs are early diagnosed and successfully treated, in a small percentage of patients with giant cSCC (maximum diameter >5 cm), metastases may occur; treatment options are limited and not really effective. We report the case of a giant metastatic cSCC that had been neglected for more than 20 years. Radiotherapy or surgery were not feasible and polichemotherapy (cisplatin, 5-fluorouracil and paclitaxel) was not effective. Therefore, the patient was treated with palliative electrochemotherapy (ECT) achieving a partial reduction of cutaneous metastasis and pain relief but unfortunately the patient died 3 months after the second ECT treatment.
References
Jan 1, 1994·Dermatology : International Journal for Clinical and Investigative Dermatology·D CzarneckiC Meehan
Feb 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gary L ClaymanScott M Lippman
Aug 3, 2006·The British Journal of Dermatology·B A RaaschC Garbe
Nov 23, 2006·Archives of Dermatology·Peter D BaadeJoanne F Aitken
Oct 4, 2007·The Journal of Craniofacial Surgery·Othon PapadopoulosAlkiviadis Kostakis
Jan 25, 2008·The Journal of Craniofacial Surgery·Kara KrajewskiJames P Bradley
May 15, 2008·Journal of Medical Imaging and Radiation Oncology·M J Veness
Dec 15, 2010·Journal of Skin Cancer·Erika VargaLajos Kemény
Jan 19, 2011·Archives of Dermatology·Susan A OliveriaAllan C Halpern
Aug 4, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eve MaubecMarie-Françoise Avril
May 5, 2012·Journal of Cutaneous and Aesthetic Surgery·Uwe WollinaAndreas Nowak
Jan 5, 2013·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Ioannis Manousaridis, Martin Leverkus
May 17, 2013·JAMA Dermatology·Chrysalyne D SchmultsAbrar A Qureshi
Oct 1, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·G Di MontaN Mozzillo
Jun 7, 2014·Dermatologic Therapy·F RicottiA Offidani
Citations
May 13, 2017·Journal of Medical Case Reports·Evangelos P MisiakosAnastasios Machairas
Feb 20, 2016·Plastic and Reconstructive Surgery. Global Open·Lisa M BlockSamuel O Poore
Jun 15, 2021·Cancer Treatment and Research Communications·Valerie van DamLambert Julien
Aug 12, 2019·International Journal of Surgery Case Reports·P A LópezH Conrado