Giant prolactinomas presenting as skull base tumors

Surgical Neurology
Giuseppe MinnitiGiampaolo Cantore

Abstract

Prolactinomas invading the skull base are rare, and could easily be confused with skull base tumors of nonpituitary origin. We report a series of 4 cases of giant prolactinomas invading the skull base and presenting with atypical symptoms. Case 1 presented with a short history of headache and nasal obstruction. Case 2 presented with progressive hypoacusia, dizziness, and ophthalmoplegia. In Case 3, the patient developed rapid progressive visual failure and psychiatric symptoms. Case 4 presented with a 1-year history of headache and retrorbital pain. The diagnosis of prolactinoma was made on the basis of tumor immunohistochemistry and/or high plasma prolactin levels (range from 650-6,500 ng/mL). Medical treatment with the dopamine agonist cabergoline was given; it was effective in normalizing prolactin levels and inducing tumor shrinkage. Prolactin levels should be measured in all large skull base tumors involving the pituitary region before any surgery or inappropriate radiotherapy is performed.

References

Mar 1, 1991·Clinical Endocrinology·G Faglia
Jul 1, 1987·Surgical Neurology·M KurokiF Ikuta
Oct 1, 1986·The Journal of Clinical Endocrinology and Metabolism·C FerrariA Dubini
Mar 1, 1986·Journal of Neurosurgery·W R SelmanS M Carpenter
Sep 12, 1985·The New England Journal of Medicine·A LiuzziG Luccarelli
Aug 1, 1982·Clinical Endocrinology·J D Nabarro
Oct 1, 1995·Clinical Endocrinology·L G Sobrinho
Jan 1, 1994·British Journal of Neurosurgery·R J CookB A Bell

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Citations

Jan 18, 2006·Pituitary·Chonjiang YuJian Gong
Dec 28, 2005·Pituitary·Arijit ChattopadhyayShariq R Masoodi
Jul 19, 2012·The Journal of Laryngology and Otology·R H CareP G Harries
Jan 19, 2013·QJM : Monthly Journal of the Association of Physicians·P Iglesias, J J Díez
Feb 19, 2014·European Journal of Endocrinology·Dominique Maiter, Etienne Delgrange
Dec 18, 2007·Annales d'endocrinologie·Gianluca TamagnoAlbert Beckers
Jun 25, 2013·Der Radiologe·M NeubacherK Hauenstein
May 15, 2013·Clinical Endocrinology·Aline B MoraesMônica R Gadelha
May 1, 2015·BMJ Case Reports·Jaya Prakash SahooVivekanandan Pillai
Jul 27, 2014·Pituitary·Mussa H AlmalkiNaji Aljohani
Oct 6, 2016·Endocrine·Paula Andujar-PlataIgnacio Bernabeu
Apr 30, 2007·The Neuroradiology Journal·N K Al-ZadjaliA Al Azzaz
Jul 24, 2007·Arkhiv patologii·D E MatskoN V Markova
Apr 18, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Oksana HamidiIrina Bancos
May 1, 2008·Expert Review of Endocrinology & Metabolism·Marcello D Bronstein
Aug 26, 2009·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Shrikrishna V AcharyaNalini S Shah
May 18, 2006·Endocrine Reviews·Mary P GillamAnnamaria Colao
Jul 26, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ilgin Yildirim SimsirAhmet Gokhan Ozgen
Jul 17, 2021·Journal of the Endocrine Society·Aleksandra SliwinskaFaryal S Mirza

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