Giant Somatosensory Evoked Potentials Coincident With Epileptiform Discharges in Acutely Comatose Patients

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
D A HouldenG Bryan Young

Abstract

The amplitude of the cortically generated somatosensory evoked potential (SSEP) is used to predict outcome in comatose patients. The relationship between epileptiform discharges and SSEP amplitude has not been elucidated in those patients. Bilateral median nerve SSEP and electroencephalograph (EEG) studies were performed in a comatose patient (patient 1) 1 day after cardiac surgery and repeated 4 days later. He had tranexamic acid administered before and during surgery. Another comatose patient (patient 2) had the same studies performed 1 day after sustaining 10 minutes of pulseless electrical cardiac activity. Both comatose patients had epileptiform discharges (on EEG) that were coincident with giant cortically generated SSEPs. In patient 1, the EEG and SSEP studies repeated 5 days postoperatively showed no epileptiform discharges, and the cortically generated SSEP amplitude was decreased (normalized) compared with that obtained one day postoperatively. He emerged from coma and had a good recovery. Patient 2 died shortly after EEG and SSEP testing. Epileptiform discharges were associated with giant cortically generated median nerve SSEP amplitude (tranexamic acid was implicated in patient 1 and anoxic brain injury in patient 2...Continue Reading

References

Mar 1, 1985·Brain : a Journal of Neurology·H ShibasakiR Fukui
Nov 14, 1997·Neurophysiologie clinique = Clinical neurophysiology·P ViglianoR Rigardetto
Nov 5, 1999·Neurophysiologie clinique = Clinical neurophysiology·J M Guérit
Mar 22, 2002·The Journal of Pharmacology and Experimental Therapeutics·Roman FurtmüllerHeinz Redl
Nov 18, 2004·Muscle & Nerve·Hiroshi Shibasaki, Mark Hallett
Sep 15, 2005·Neurocritical Care·G Bryan YoungAldo Ragazzoni
Jan 1, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Juha Silvanto, Neil G Muggleton
Jan 1, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Martin Schorl
Dec 4, 2009·Journal of Hazardous Materials·Lúcia H M L M SantosM C B S M Montenegro

❮ Previous
Next ❯

Citations

Jun 20, 2019·Critical Care : the Official Journal of the Critical Care Forum·Sang Hoon OhSeong Hoon Kim
May 20, 2020·Frontiers in Neurology·Astrid B GlimmerveenJeannette Hofmeijer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.