Giant Transposons in Eukaryotes: Is Bigger Better?

Genome Biology and Evolution
I R Arkhipova, Irina A Yushenova

Abstract

Transposable elements (TEs) are ubiquitous in both prokaryotes and eukaryotes, and the dynamic character of their interaction with host genomes brings about numerous evolutionary innovations and shapes genome structure and function in a multitude of ways. In traditional classification systems, TEs are often being depicted in simplistic ways, based primarily on the key enzymes required for transposition, such as transposases/recombinases and reverse transcriptases. Recent progress in whole-genome sequencing and long-read assembly, combined with expansion of the familiar range of model organisms, resulted in identification of unprecedentedly long transposable units spanning dozens or even hundreds of kilobases, initially in prokaryotic and more recently in eukaryotic systems. Here, we focus on such oversized eukaryotic TEs, including retrotransposons and DNA transposons, outline their complex and often combinatorial nature and closely intertwined relationship with viruses, and discuss their potential for participating in transfer of long stretches of DNA in eukaryotes.

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Citations

Jan 11, 2020·Molecular Biology Reports·Marwa GhonaimAlan H Schulman
Apr 2, 2020·Biological Chemistry·Iana V KimClaus-D Kuhn
Apr 26, 2020·International Journal of Molecular Sciences·Ruslan KalendarAlan H Schulman
Feb 15, 2020·Scientific Reports·Olivia SanllorenteTeresa Palomeque
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Mar 7, 2021·International Journal of Molecular Sciences·Anna Maria PappalardoTeresa Capriglione
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Jul 3, 2021·Animals : an Open Access Journal From MDPI·Cai ChenChengyi Song

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Methods Mentioned

BETA
gene exchange
ICEs
ICE
ubiquitination
gypsy

Software Mentioned

HHpred
Polintons
MULEs
Pack
Helitrons

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