Gibberellin DELLA signaling targets the retromer complex to redirect protein trafficking to the plasma membrane

Proceedings of the National Academy of Sciences of the United States of America
Yuliya SalanenkaJiří Friml

Abstract

The plant hormone gibberellic acid (GA) is a crucial regulator of growth and development. The main paradigm of GA signaling puts forward transcriptional regulation via the degradation of DELLA transcriptional repressors. GA has also been shown to regulate tropic responses by modulation of the plasma membrane incidence of PIN auxin transporters by an unclear mechanism. Here we uncovered the cellular and molecular mechanisms by which GA redirects protein trafficking and thus regulates cell surface functionality. Photoconvertible reporters revealed that GA balances the protein traffic between the vacuole degradation route and recycling back to the cell surface. Low GA levels promote vacuolar delivery and degradation of multiple cargos, including PIN proteins, whereas high GA levels promote their recycling to the plasma membrane. This GA effect requires components of the retromer complex, such as Sorting Nexin 1 (SNX1) and its interacting, microtubule (MT)-associated protein, the Cytoplasmic Linker-Associated Protein (CLASP1). Accordingly, GA regulates the subcellular distribution of SNX1 and CLASP1, and the intact MT cytoskeleton is essential for the GA effect on trafficking. This GA cellular action occurs through DELLA proteins t...Continue Reading

References

Jan 1, 1991·Pharmacology & Therapeutics·L C Morejohn, D E Fosket
Mar 9, 2002·Science·F Ulrich Hartl, Manajit Hayer-Hartl
Mar 1, 2003·Nature·Xiangdong Fu, Nicholas P Harberd
Mar 22, 2003·Science·Nicholas P Harberd
Mar 29, 2003·The Plant Journal : for Cell and Molecular Biology·Jirí FrimlGerhard Muster
May 14, 2003·Trends in Cell Biology·Pedro CarvalhoDavid Pellman
Sep 6, 2003·Current Biology : CB·Nathalie Le BotJulie Ahringer
Nov 25, 2003·The Journal of Biological Chemistry·C Torrey SimonsNicholas J Cowan
Mar 12, 2004·Annual Review of Plant Physiology and Plant Molecular Biology·Wilhelm Rademacher
Oct 29, 2004·Plant & Cell Physiology·Masayoshi NakamuraTakashi Hashimoto
Jan 22, 2005·Current Opinion in Cell Biology·Anna Akhmanova, Casper C Hoogenraad
Dec 7, 2005·Proceedings of the National Academy of Sciences of the United States of America·Tomasz J ProszynskiChristiane Walch-Solimena
Feb 20, 2007·Current Biology : CB·Pankaj DhonuksheJirí Friml
May 3, 2007·Annual Review of Plant Biology·Miyako Ueguchi-TanakaMakoto Matsuoka
Jul 10, 2007·Plant Physiology·David Weiss, Naomi Ori
Apr 9, 2008·Current Biology : CB·Jürgen Kleine-VehnJirí Friml
Sep 23, 2008·Plant Molecular Biology·Eva Benková, Jan Hejátko
Nov 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jürgen Kleine-VehnJirí Friml
Mar 24, 2009·Cell·Steffen Vanneste, Jirí Friml
Oct 15, 2009·Molecular Plant·Jürgen Kleine-VehnJirí Friml
Jul 8, 2010·Current Biology : CB·Laila MoubayidinSabrina Sabatini
May 6, 2011·Plant Physiology·Javier Gallego-BartoloméMiguel A Blázquez
Jun 15, 2011·Cell Research·Marta ZwiewkaJiří Friml
May 5, 2012·Proceedings of the National Academy of Sciences of the United States of America·Johannes LeitnerChristian Luschnig
Nov 14, 2012·Journal of Cell Science·Matthew N J Seaman
Feb 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Christian LöfkeJirí Friml
Apr 16, 2013·Current Biology : CB·Antonella LocascioDavid Alabadí
Jan 22, 2015·The Plant Cell·Maciek Adamowski, Jiří Friml
Dec 31, 2015·Proceedings of the National Academy of Sciences of the United States of America·David ScheuringJürgen Kleine-Vehn

❮ Previous
Next ❯

Citations

Mar 23, 2018·Proceedings of the National Academy of Sciences of the United States of America·Yonglun ZengLiwen Jiang
Jul 25, 2019·International Journal of Molecular Sciences·Abu Imran BabaÁgnes Cséplő
Dec 11, 2019·International Journal of Molecular Sciences·Abu Imran BabaÁgnes Cséplő
May 20, 2020·Frontiers in Plant Science·Judith García-GonzálezKateřina Schwarzerová
Mar 19, 2021·Plant Physiology·Madhumitha NarasimhanJiří Friml
Jul 14, 2021·The New Phytologist·Huibin HanJiří Friml
Apr 28, 2021·Cold Spring Harbor Perspectives in Biology·Serina M Mazzoni-PutmanAnna N Stepanova
Sep 18, 2021·Plant Biotechnology Journal·Jia Dong, Matthew E Hudson

❮ Previous
Next ❯

Methods Mentioned

BETA
fluorescence recovery after photobleaching
reverse transcription PCR
PCRs

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Christian LöfkeJiří Friml
Proceedings of the National Academy of Sciences of the United States of America
Yunlong DuJiří Friml
Proceedings of the National Academy of Sciences of the United States of America
Jürgen Kleine-VehnJiří Friml
Annual Review of Plant Biology
Julio Paez ValenciaMarisa S Otegui
© 2022 Meta ULC. All rights reserved